Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Population Briefs, Vol. 18, no. 1 [PDF]
, 2012 IN THIS ISSUE: Population Council research defines broad benefits of family planning | Council-partnered family planning foundation significantly reduces risk of unintended pregnancy among poor women in the United States | Council research offers ...
Population Council
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Women and HIV: Understanding and addressing stigma—Evidence from the Population Council [PDF]
, 2019 Over the last 20 years, the Population Council has carried out extensive work examining the intersection of stigma and gender and its impact on HIV-related outcomes.
Population Council
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Human Vaccines & ImmunotherapeuticsFollowing the termination of China’s dynamic zero-COVID-19 policy at the end of 2022, this study aimed to compare rabies post-exposure prophylaxis (PEP) patterns between 2022 and 2023 and to analyze the specific effects of nonpharmaceutical interventions
Yan-Tao Du +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Preventing pediatric tuberculosis: A randomized trial of symptom-based screening of South African children exposed to tuberculosis [PDF]
, 2017 In South Africa, a country with one of the highest levels of HIV prevalence, HIV-positive adults are the source case for a large proportion of pediatric tuberculosis (TB) cases.
Population Council
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Retracted: Study on Psychological Stress Response and Intervention Countermeasures of Exposed Population under Sudden Public Health Crisis. [PDF]
Biomed Res Int, 2023 International BR.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Population policy under an arbitrary welfare criterion : theory and issues [PDF]
, 1972 For more about the East-West Center, see http://www.eastwestcenter.org/Many well-defined policy problems can be formally described as follows: Let x(t) be an n-dimensional vector describing the state of a system at time t , and y(t) be an m-dimensional ...
Arthur, W. Brian +1 more
core +1 more source