Results 81 to 90 of about 6,134,651 (270)

Mortality in New Zealand workers exposed to phenoxy herbicides and dioxins. [PDF]

, 2004
AIMS: To evaluate mortality in New Zealand phenoxy herbicide producers and sprayers exposed to dioxins. METHODS: Phenoxy herbicide producers (n = 1025) and sprayers (n = 703) were followed up from 1 January 1969 and 1 January 1973 respectively to 31 ...
McLean, D, Boffetta, P, 't Mannetje, A, Colin, D, Pearce, N., Cheng, S., Colin, D., Cheng, S, Pearce, N, 'T Mannetje, A., McLean, D., Boffetta, P., A 't Mannetje   +12 more
core   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Hyperparasitism in a Generalist Ectoparasitic Pupal Parasitoid, Pachycrepoideus vindemmiae (Hymenoptera: Pteromalidae), on Its Own Conspecifics: When the Lack of Resource Lead to Cannibalism.

PLoS ONE, 2015
Hyperparasitism is a normal behavior of parasitoids, which often happens among species. Conspecific hyperparasitism, such as some kinds of heteronomous hyperparasitic behaviors, has been only reported in some species belonging to Aphelinidae.
Wei Chen, Zhang He, Xiao-Li Ji, Si-Ting Tang, Hao-Yuan Hu   +4 more
doaj   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Offspring of parents with recurrent depression: which features of parent depression index risk for offspring psychopathology? [PDF]

, 2012
Background: Parental depression is associated with an increased risk of psychiatric disorder in offspring, although outcomes vary. At present relatively little is known about how differences in episode timing, severity, and course of recurrentdepression ...
Sellers, R., Frances Rice (11378531), Sellers, Ruth, Harold, G.T., Potter, Robert, Stephan Collishaw, Nicholas Craddock (613070), Anita Thapar (766569), Robert Potter (3455717), Daniel Smith (6120), Daniel Smith, Anita Thapar, Gordon T. Harold, Craddock, Nicholas John, Stephan Collishaw (766570), Becky Mars, Smith, Daniel, Thapar, Anita, Ruth Sellers (4465924), Ruth Sellers, Harold, Gordon Thomas, Rice, Frances, Thapar, A., Collishaw, S., Thapar, Ajay Kumar, Thapar, Ajay, Robert Potter, Craddock, N., Ajay Thapar, Ajay Thapar (16221035), Collishaw, Stephan, Becky Mars (766567), Gordon Harold (4464610), Potter, R., Craddock, Nicholas, Frances Rice, Rice, F., Harold, Gordon T, Mars, Becky, Nicholas Craddock, Mars, B., Smith, Daniel J., Smith, D.   +42 more
core   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Association between Maternal Depression Symptoms across the First Eleven Years of Their Child's Life and Subsequent Offspring Suicidal Ideation.

PLoS ONE, 2015
Depression is common, especially in women of child-bearing age; prevalence estimates for this group range from 8% to 12%, and there is robust evidence that maternal depression is associated with mental health problems in offspring.
Gemma Hammerton, Liam Mahedy, Becky Mars, Gordon T Harold, Anita Thapar, Stanley Zammit, Stephan Collishaw   +6 more
doaj   +1 more source

Cancer morbidity among methyl isocyanate exposed long- term survivors and their offspring: a hospital-based five year descriptive study (2006 - 2011) and future directions to predict cancer risk in the affected population.

Asian Pacific journal of cancer prevention : APJCP, 2012
The purpose of this study was to update both researchers and clinicians about the cancer incidence in methyl isocyanate (MIC) exposed long-term survivors and in their offspring, focusing on the etiological plausibility. In the time period 2006-2011, cancer morbidity was evaluated in the population surviving after exposure to (MIC) on December 3rd, 1984,
Chinnu Sugavanam, Senthilkumar, Tahir Mohi-ud-Din, Malla, Nand Kishore, Sah, Narayanan, Ganesh   +3 more
openaire   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source