Results 61 to 70 of about 10,673 (169)

Risk Evaluation of Endocrine-Disrupting Chemicals

Dose-Response, 2015
We review here our studies on early exposure to low doses of the estrogenic endocrine-disrupting chemical bisphenol A (BPA) on behavior and metabolism in CD-1 mice.
Laura Gioiosa, Paola Palanza, Stefano Parmigiani, Frederick S. vom Saal   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

ON THE ADVISABILITY OF REJECTION OF SUBTRACTION OF BACKGROUND DOSIMETERS INDICATION VALUES FROM THE MEASURED VALUES OF INDIVIDUAL DOSES OF OCCUPATIONAL EXPOSURE OF A-GROUP PERSONNEL

Радиационная гигиена, 2015
An article contains substantiation of advisability of rejection of subtraction of background dosimeters indication values from the measured values of individual doses of occupational exposure of A-group personnel in the process of carrying out of ...
A. N. Barkovskiy
doaj  

Evaluation of effects, inheritance patterns and gene number prediction controlling plant height and root length of colchicine treated fennel (Foeniculum vulgare Mill.)

Maǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ
Fennel seeds were treated with varying colchicine concentrations (0, 0.0125, 0.025, 0.05, 0.1, and 0.2 % w/v) for 24 and 48 hours and then planted in a garden using a randomized complete block design (RCBD) method.
Manisha Hariwal , Sanjay Kumar
doaj   +1 more source

Statement on the findings in recent studies investigating sub‐lethal effects in bees of some neonicotinoids in consideration of the uses currently authorised in Europe

EFSA Journal, 2012
The European Food Safety Authority was requested to perform a comparison between the doses of several neonicotinoids tested in the studies from Henry et al.
European Food Safety Authority
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source