Results 71 to 80 of about 6,692 (215)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

COMPARISON OF RUSSIAN AND FOREIGN HYGIENIC PARAMETERS OF MEDICINES PERMISSIBLE EXPOSURE LIMIT

Разработка и регистрация лекарственных средств, 2019
Hygienic standardization of harmful substances in the air of the working area, aimed at maintaining the health of workers is an essential attribute of any chemical production, including pharmaceutical producing.
S. S. Rozhkov, A. V. Smirnov
doaj  

Comparison of occupational exposure limits in China with threshold limit values announced by American Conference of Governmental Industrial Hygienists

环境与职业医学
BackgroundThe threshold limit values (TLVs) established and regularly updated by the American Conference of Governmental Industrial Hygienists (ACGIH) are widely adopted and referenced globally, serving as a crucial reference for China's occupational ...
Qiangzhi GUO, Yazhen WANG, Yuntao MU, Jinling LIU, Xue JIANG, Di LIU, Chen SHEN, Lingling LI, Yi LIU   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Extrapolation of Experimental Field Study to a National Occupational Noise Exposure Standard [PDF]

International Journal of Occupational Hygiene, 2010
Proposing a Noise Standards should be considered seriously by the governmental authorities because of the prevalence of hazardous noise exposure and the seriousness of the effects.
Mohammad Javad Jafari, Ali Karimi, Mahin Haghshenas   +2 more
doaj   +1 more source

Concerns regarding the quality and number of Occupational Exposure Limit Values

Safety and Health at Work, 2022
Hans Thore Smedbold
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Modern health worries and exposure perceptions of individuals reporting varying levels of sensitivity to electromagnetic fields: results of two successive surveys

Frontiers in Public Health
IntroductionIndividuals who claim to be affected by idiopathic environmental intolerance attributed to electromagnetic fields (EMFs) report symptoms linked to EMF exposure.
Maryse Ledent, Maryse Ledent, Benjamin Vatovez, Philippe Roelandt, Jimmy Bordarie, Maël Dieudonné, Els De Waegeneer, Caroline Kremer, Laura Boucher, Catherine Bouland, Eva Maria De Clercq   +10 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source