Results 101 to 110 of about 1,615,397 (338)

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Multi-Exposure Image Fusion Based on Exposure Compensation [PDF]

open access: yesarXiv, 2018
This paper proposes a novel multi-exposure image fusion method based on exposure compensation. Multi-exposure image fusion is a method to produce images without color saturation regions, by using photos with different exposures. However, in conventional works, it is unclear how to determine appropriate exposure values, and moreover, it is difficult to ...
arxiv  

Limit Order Strategic Placement with Adverse Selection Risk and the Role of Latency [PDF]

open access: yes, 2016
This paper is split in three parts: first we use labelled trade data to exhibit how market participants accept or not transactions via limit orders as a function of liquidity imbalance; then we develop a theoretical stochastic control framework to ...
Charles-Albert Lehalle, Othmane Mounjid
semanticscholar   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

Avaliação ocupacional quantitativa das temperaturas extremas em um laboratório acadêmico: os reflexos da exposição para a saúde dos trabalhadores

open access: yesRevista Principia, 2019
Every day occupational diseases incapacitate thousands of workers in a wide range of activities causing problems which vary from temporary retirements until death The diseases usually start when there is exposure to physical environmental agents above ...
Mayslane de Sousa Gomes   +3 more
doaj   +1 more source

Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention

open access: yesEnvironmental Health, 2013
BackgroundDue to global mercury pollution and the adverse health effects of prenatal exposure to methylmercury (MeHg), an assessment of the economic benefits of prevented developmental neurotoxicity is necessary for any cost-benefit analysis ...
M. Bellanger   +24 more
semanticscholar   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

open access: yesMolecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park   +6 more
wiley   +1 more source

Modeling User Exposure in Recommendation [PDF]

open access: yesarXiv, 2015
Collaborative filtering analyzes user preferences for items (e.g., books, movies, restaurants, academic papers) by exploiting the similarity patterns across users. In implicit feedback settings, all the items, including the ones that a user did not consume, are taken into consideration.
arxiv  

Identification of Vancomycin Exposure-Toxicity Thresholds in Hospitalized Patients Receiving Intravenous Vancomycin

open access: yesAntimicrobial Agents and Chemotherapy, 2017
Evidence supports vancomycin therapeutic-drug monitoring by area under the concentration-time curve (AUC), but data to establish an AUC upper limit are limited and published nephrotoxicity thresholds range widely.
E. Zasowski   +6 more
semanticscholar   +1 more source

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