Results 171 to 180 of about 1,615,131 (338)

Screening values for Non-Carcinogenic Hanford Waste Tank Vapor Chemicals that Lack Established Occupational Exposure Limits

, 2006
Torka S. Poet, T.J. Mast, J.L. Huckaby
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Extractables and Leachables in Pharmaceutical Products: Potential Adverse Effects and Toxicological Risk Assessment. [PDF]

Toxics
Kuzmič S, Zlobec T, Dolenc MS, Roškar R, Lušin TT.   +4 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Mycotoxins Co-Exposure Risk Assessment in Coix Seed: Contamination Levels and Safety for Dietary Consumption and Medicinal Intake. [PDF]

Foods
Han Y, Wang L, Yuan Q, Guo L, Kang C, Yang Y, Xiao C, Yang C, Zhang J, Zhou T.   +9 more
europepmc   +1 more source

Testing the coherence between occupational exposure limits for inhalation and their biological limit values with a generalized PBPK-model: The case of 2-propanol and acetone

, 2014
Daan Huizer, Mark A. J. Huijbregts, Joost G.M. van Rooij, Ad M.J. Ragas   +3 more
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Biological monitoring of occupational exposure to inorganic lead: a comparison between salivary, blood and airborne lead levels. [PDF]

Environ Health
Tobia L, Mastrantonio R, Muselli M, De Rossi L, Tolli E, Cofini V, Grignani E, Gambelunghe A, Dell'Omo M, Necozione S, Fabiani L.   +10 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Worker exposure to persistent organic pollutants, as polybrominated diphenyl ethers, and biological hazards during the processing of waste upholstered domestic seating in Great Britain. [PDF]

Ann Work Expo Health
Gosling RJ, Simpson AT, Bailey C, Baldwin PEJ, Lord S.   +4 more
europepmc   +1 more source