Results 111 to 120 of about 1,709,399 (340)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Realidade virtual no tratamento do transtorno de pânico Virtual reality in treatment of panic disorder

Jornal Brasileiro de Psiquiatria, 2008
O uso de realidade virtual (RV) é útil no tratamento de exposição em pacientes com transtorno de pânico (TP). Em ambientes virtuais, os pacientes experimentam alterações fisiológicas, psíquicas e somáticas similares aos sintomas em situações da vida real,
Marcele Regine de Carvalho, Rafael C. Freire, Antonio Egidio Nardi   +2 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Adjunct psychomotor trauma exposure in the treatment of post-traumatic stress disorder: a case series

European Journal of Psychotraumatology
Introduction: Psychotraumatic disorders, particularly post-traumatic stress disorder (PTSD), have been a major public health issue for many years. However, many patients remain resistant to treatment, with significant levels of residual symptoms, a high ...
Claire Guépin, Stéphane Duhem, Nicolas Gaud, Frédérique Warembourg, Guillaume Vaiva, Arnaud Leroy   +5 more
doaj   +1 more source

The Bergen 4-Day Treatment for Obsessive-Compulsive Disorder: Does It Work in a New Clinical Setting?

Frontiers in Psychology, 2019
Sørlandet Hospital in Norway has a history of offering patients with obsessive-compulsive disorder (OCD) cognitive behavior group therapy using 12 weekly sessions of 2.5 h each. A previous evaluation of this treatment has shown that 51.9% did not respond
Gunvor Launes, Gunvor Launes, Inger Lill Laukvik, Inger Lill Laukvik, Tor Sunde, Ingrid Klovning, Kristen Hagen, Kristen Hagen, Stian Solem, Stian Solem, Lars-Göran Öst, Lars-Göran Öst, Bjarne Hansen, Bjarne Hansen, Gerd Kvale, Gerd Kvale   +15 more
doaj   +1 more source

The influence of Helicobacter pylori on oesophageal acid exposure in GERD during acid suppressive therapy [PDF]

, 1999
Peters, Kuipers, Ganesh, Sluiter, Klinkenberg‐Knol, Lamers, Kleibeuker   +6 more
openalex   +1 more source

Brain Resilience: Shedding Light into the Black Box of Adventure Processes [PDF]

, 2012
Understanding of the active beneficial processes of adventure learning remains elusive. Resilience may provide one foundation for understanding the positive adaptation derived from Outdoor Adventure Education (OAE) and Adventure Therapy (AT) programming.
Allan, J, Hind, K, McKenna, J
core  

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Innovative Approaches to Eating Disorders Treatment: A Systematic Review on the Effectiveness of Virtual Reality

Applied Sciences
This systematic review investigates the effectiveness of virtual reality as a tool in the treatment of eating disorders, either alone or in combination with other therapies.
Mariona Arrom-Llabrés, María Teresa Mendoza-Medialdea, José Gutiérrez-Maldonado   +2 more
doaj   +1 more source