Results 71 to 80 of about 1,030,749 (262)

Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review

European Journal of Psychotraumatology, 2013
There is a good amount of evidence that exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD). Notwithstanding its efficacy, there is room for improvement, since a large proportion of patients does not benefit from treatment.
Rianne A. de Kleine, Barbara O. Rothbaum, Agnes van Minnen   +2 more
doaj   +1 more source

Improving Exposure Therapy

Psychiatric Clinics of North America
Funder: http://dx.doi.org/10.13039/501100000925 National Health and Medical Research ...
Jasper A.J. Smits, Jonathan S. Abramowitz, Joanna J. Arch, Santiago Papini, Rebecca A. Anderson, Laura J. Dixon, Bronwyn M. Graham, Stefan G. Hofmann, Jürgen Hoyer, Jonathan D. Huppert, Jolene Jacquart, David Johnson, Peter M. McEvoy, Dean McKay, Jill Newby, Michael W. Otto, Andre Pittig, Winfried Rief, David Rosenfield, Kiara R. Timpano, Andre Wannemüller   +20 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Virtually Unexpected: No Role for Expectancy Violation in Virtual Reality Exposure for Public Speaking Anxiety

Frontiers in Psychology, 2019
In the current study, we examined the role of expectancy violation and retrospective reasoning about the absence of feared outcomes in virtual reality exposure therapy (VRET). Participants fearful of public speaking were asked to give speeches in virtual
Sara Scheveneels, Yannick Boddez, Yannick Boddez, Tom Van Daele, Dirk Hermans   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exposure Therapy for Phobias

Europe’s Journal of Psychology, 2013
Reid Wilson’s approach to treating anxiety disorders draws upon cognitive behavior therapy techniques to create a brief, aggressive, paradoxical treatment for people who suffer from anxiety disorders. Research has shown that exposure therapy is by far the most effective way to get lifelong results in the treatment of specific phobias.
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

RESET post-traumatic stress disorder: clinical protocol integrating reconsolidation, exposure, short-term emotional transformation

European Journal of Psychotraumatology
Background: The RESET (Reconsolidation, Exposure, and Short-term Emotional Transformation) clinical protocol is an intensive, structured trauma-focused intervention designed to treat post-traumatic stress disorder (PTSD) within six daily sessions.
Dori Rubinstein, Maayan Abargil, Or Duek, Ilan Harpaz-Rotem   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source