Results 81 to 90 of about 1,028,562 (262)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities: the BEAMS-ID feasibility study

Health Technology Assessment
Background Interventions for anxiety need to be adapted to meet the needs of autistic people with moderate to severe learning disabilities and successfully modelled before evidence about efficacy can be generated from clinical trials.
Peter E Langdon, Magdalena M Apanasionok, Emma Scripps, Karen Bunning, Malwina Filipczuk, David Gillespie, Richard P Hastings, Andrew Jahoda, Rachel McNamara, Dheeraj Rai, Kylie M Gray   +10 more
doaj   +1 more source

Integrating autonomic and affective pathways in borderline personality disorder: the triangle therapy hypothesis

Frontiers in Psychology
IntroductionBorderline personality disorder is marked by emotional lability, unstable identity, and hypersensitivity to abandonment. Although mainstream treatments, such as dialectical behavior therapy, schema therapy, and mentalization-based therapy ...
Daniel Juraszek
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Improving Exposure Therapy

Psychiatric Clinics of North America
Funder: http://dx.doi.org/10.13039/501100000925 National Health and Medical Research ...
Jasper A.J. Smits, Jonathan S. Abramowitz, Joanna J. Arch, Santiago Papini, Rebecca A. Anderson, Laura J. Dixon, Bronwyn M. Graham, Stefan G. Hofmann, Jürgen Hoyer, Jonathan D. Huppert, Jolene Jacquart, David Johnson, Peter M. McEvoy, Dean McKay, Jill Newby, Michael W. Otto, Andre Pittig, Winfried Rief, David Rosenfield, Kiara R. Timpano, Andre Wannemüller   +20 more
openaire   +2 more sources

Mental health clients’ perspectives on telehealth-based virtual reality therapy

Frontiers in Virtual Reality
There is growing need for better mental health care. It is now possible to combine convenient telehealth with engaging virtual reality towards new opportunities for personalized mental health.
Triton Ong, Julia Ivanova, Hiral Soni, Janelle Barrera, Janelle Barrera, Mollie Cummins, Mollie Cummins, Brandon M. Welch, Brandon M. Welch, Brian E. Bunnell, Brian E. Bunnell   +10 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Technique: Exposure Therapy

Bilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi, 2013
Introduction: Exposure with response prevention is an effective treatment for all anxiety disorders. According to the behavioral learning theories, fears which are conditioned via classical conditioning are reinforced by respondent conditioning. Avoidance and safety seeking behaviors prevent disconfirmation of anxious beliefs.
Serkan AKKOYUNLU, M. Hakan TÜRKÇAPAR   +1 more
openaire   +3 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source