Results 131 to 140 of about 422,721 (317)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Biological agents in the workplace – risk assessment [PDF]

, 2008
Zgodnie z rozporządzeniem ministra zdrowia w sprawie szkodliwych czynników biologicznych dla zdrowia w środowisku pracy oraz ochrony zdrowia pracowników zawodowo narażonych na te czynniki (Dz.U. nr 81/2005, poz.
Zapór, L., Gołofit-Szymczak, M.
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

“Acute problem” – what to do following occupational exposure [PDF]

, 2015
Ekspozycja zawodowa na czynniki biologiczne to problem dotyczący personelu medycznego, którego praca związana jest w bezpośredni sposób z pacjentem. Przestrzeganie zasad postępowania z materiałem potencjalnie zakaźnym jest podstawową metodą zapobiegania ...
Prochota, Barbara
core  

[Workers' exposure to selected biological agents in libraries of Upper Silesia].

Medycyna pracy, 2008
The aim of this study was to assess the exposure of library workers to biological agents based on quantitative and qualitative characteristics of airborne and settled dust microflora supplemented with the analysis of dust mite allergens. The bioaerosol sampling was carried out using a 6-stage Andersen impactor.
Agnieszka, Wlazło, Rafał L, Górny, Renata, Złotkowska, Anna, Lawniczek, Beata, Ludzeń-Izbińska, Aleksander S, Harkawy, Edmund, Anczyk   +6 more
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Epidemiological transition. The other side of the coin [PDF]

, 2006
The model of epidemiological transition proposed by Omram explains the changes in disease patterns in communities. In societies with a high level of development this model has been complemented with the study of the post transition process.
Valdivia C, Gonzalo
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

[Mucocutaneous candidiasis in exposure to biological agents: a clinical case].

La Medicina del lavoro, 1993
Candida albicans, an ubiquity yeast, has several properties which allow it colonize and invade host tissues, often resisting eradication. Acid proteinase is the virulence factor. Bacterial proteinases are widely used in the detergent industry and the role of occupational exposure to enzymes in the development of mucocutaneous candidosis warrants ...
openaire   +1 more source