Results 141 to 150 of about 6,972,561 (305)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Efficient extracellular expression of transpeptidase sortase A in Pichia pastoris
, 2017 In order to achieve efficient extracellular expression of Sortase A (SrtA), various strategies in Pichia pastoris system were applied in this study. Among different constructed recombinant strains, the SMD1168 strain integrated 5.7 copies of srtA gene ...
Hong, Haofei +5 more
core +1 more source
The Journal of Physiology, 2011 The Journal of Physiology has been informed by Bente Klarlund Pedersen, MD, DMSc, Professor of Integrative Medicine, Director of the Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC Rigshospitalet at the University of Copenhagen Faculty of Health Sciences, Copenhagen, Denmark, of concerns about the validity of some of ...
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Curriculum-based measurement in written expression at the secondary level [PDF]
, 2003 Plan BThe use of curriculum-based measurement (CBM) in written expression is becoming more common in today’s schools; however, there is a need for more information pertaining to the technical adequacy of these measures at the secondary level. As a result,
Diercks, Barbara Ann
core
Enabling Self-expression: the Use of Roles to Dynamically Change Adaptation Patterns
, 2014 Self-expression is the capability of a system of changing its adaptation pattern at runtime; this can lead to better performance still keeping the achievement of the global goal in a Collective Adaptive System (CAS).
Mariachiara Puviani +5 more
core +1 more source
Global regulation via modulation of ribosome pausing by the ABC-F protein EttA
Nature CommunicationsHaving multiple rounds of translation of the same mRNA creates dynamic complexities along with opportunities for regulation related to ribosome pausing and stalling at specific sequences.
Farès Ousalem +6 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Ensemble machine learning on gene expression data for cancer classification [PDF]
, 2003 Whole genome RNA expression studies permit systematic approaches to understanding the correlation between gene expression profiles to disease states or different developmental stages of a cell.
Tan, A C, Gilbert, D
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source