Results 151 to 160 of about 4,457,793 (257)

Comprehensive analysis of antibody-drug conjugate (ADC) targets in adenoid cystic carcinoma: examining antigen expression in relation to clinicopathological features, prognosis, and initial therapeutic outcomes. [PDF]

Transl Oncol
Wang Y, Dou S, Jiang W, Zhu L, Liu S, Gu T, Zhu G, Li J.   +7 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Glycoprotein Mucin 13 Expression as a Theranostic Target in Colorectal Cancer. [PDF]

Clin Cancer Res
Yamaguchi A, Coll RP, Wang J, Bae SW, Tran H, Huang B, Mashimo T, Schuler FW, Lin SJ, Sharma S, Dhakshinamoorthy S, Ta RT, Georgiou DK, Karacosta LG, Malik S, Khan S, Yallapu MM, Kopetz S, Chauhan SC, Manning HC.   +19 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Topological modeling of gene expression in the brain with Huntington's disease reveals selective disruption of co-expression network. [PDF]

Sci Rep
Okamura-Oho Y, Shimokawa K, Oota S, Yoshiki A, Morita M, Nishimura M, Nakamura S, Tsujimura Y, Ishikawa S, Yokota H.   +9 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Expression of protein kinase A catalytic subunits in healthy and diseased mouse kidneys. [PDF]

Pflugers Arch
Fuchs S, Majer M, Ma Y, Harloff M, Taylor S, Schlossmann J.   +5 more
europepmc   +1 more source

Viral Expression

BioTechniques, 2013
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

<i>CDKN2A</i> mRNA Over-expression Is Associated With CD8+ T Cell Exclusion and IDO1-Mediated Adaptive Immune Resistance in Gastric Adenocarcinoma. [PDF]

Cancer Diagn Progn
Lehrer S, Rheinstein P.
europepmc   +1 more source