Results 81 to 90 of about 6,972,561 (305)

Study and characterization of morphogeometric parameters to assist diagnosis of keratoconus

BioMedical Engineering OnLine, 2018
Background In case of significant imperfections on the cornea, data acquisition is difficult and a significant level of missing data could require the interpolation of important areas of the cornea, resulting in a very ambiguous model. The development of
Francisco Cavas-Martínez, Daniel G. Fernández-Pacheco, Dolores Parras, Francisco J. F. Cañavate, Laurent Bataille, Jorge Alió   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

clustering of microarray gene expression data

, 2005
Motivation: Cluster analysis of gene expression profiles has been widely applied to clustering genes for gene function discovery. Many approaches have been proposed.
Gene Expression, Wei Pan
core  

Expression quantitative trait loci are highly sensitive to cellular differentiation state [PDF]

, 2009
Blood cell development from multipotent hematopoietic stem cells to specialized blood cells is accompanied by drastic changes in gene expression for which the triggers remain mostly unknown.
Gerrits, Alice,, Xusheng Wang, Wang, Xusheng,, Breitling, Rainer, Breitling, R., Breitling, Rainer,, Gerald de Haan, Leonid V. Bystrykh, Li, Y., Dontje, B., Dontje, Bert,, Tesson, Bruno M.,, Weersing, Ellen,, Haan, Gerald de,, Bystrykh, L.V., Wang, Xusheng, Ellen Weersing, Ausema, Albertina, De Haan, Gerald, Alice Gerrits, Bert Dontje, de Haan, G., Li, Yang,, Wang, X., Gerrits, A., Bruno M Tesson, Leonid V Bystrykh, Bystrykh, Leonid V.,, Jansen, Ritsert C.,, Gerrits, Alice, Bruno M. Tesson, Jansen, Ritsert C., Rainer Breitling, Dethmers-Ausema, B, Ritsert C Jansen, Ausema, Albertina,, Albertina Ausema, Jansen, R.C., Dontje, Bert, Yang Li, Ritsert C. Jansen, Tesson, B.M., Bystrykh, Leonid V., Weersing, Ellen, de Haan, Gerald; id_orcid, Li, Yang, Tesson, Bruno M.   +46 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

DUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression [Dataset]

Compared control A253 cells with DUSP1 or SOX2 KO cells to identify differentially expressed genes.Salivary gland squamous cell carcinomas (SG-SCCs) are a rare type of head and neck cancers which are linked to poor prognosis. Due to their low frequencies,
Sastre-Perona, Ana, Acero, Lucia
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Consensus clustering and functional interpretation of gene-expression data [PDF]

, 2004
Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Liu, X, Orengo, Christine, Martin, N, Kellam, P., Paul Kellam, Liu, X., Swift, Stephen, Swift, S, Orengo, C.A., Tucker, Allan, Tucker, A., Tucker, A, Liu, XH, Allan Tucker, Vinciotti, Veronica, Christine Orengo, Veronica Vinciotti, Vinciotti, V., Xiaohui Liu, Swift, S., Kellam, P, Liu, Xiaohui, Vinciotti, V, Stephen Swift, Kellam, Paul, Orengo, C, Martin, Nigel, Nigel Martin   +27 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source