Results 91 to 100 of about 4,331,351 (268)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Expression of Cystathionine-β-Synthase (CBS) Genes in Grape under Various Abiotic Stresses and Subcellular Localization of VvCBS27

Horticulturae
The cystathionine-β-synthase (CBS) domain is present in the proteins of all living organisms and functions as an energy sensor, regulating protein activity through the binding capacity of its adenosine ligands.
Xingyun Shi, Shanshan Xu, Yandong Li, Yiming Yin   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Identification of the Chalcone Synthase Gene Family: Revealing the Molecular Basis for Floral Colour Variation in Wild Aquilegia oxysepala in Northeast China

Agronomy
Aquilegia (Ranunculaceae), a genus of perennial herbs characterized by elegant leaves and unique flowers, exhibits promising application prospects in Northeast China.
Dan Chen, Yongli Cheng, Tingting Ma, Haihang Yu, Yun Bai, Yunwei Zhou, Yuan Meng   +6 more
doaj   +1 more source

Knowledge-based gene expression classification via matrix factorization

, 2008
Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze ...
Schachtner, R., Lang, E. W., Tomé, A. M., Gómez Vilda, P., Vilda, P.G., Theis, Fabian J., Theis, F. J., Knollmüller, P., Schmitz, G., Lang, Elmar, Lang, E.W., Lutter, D., Stetter, M., Theis, F.J., Tomé, A.M.   +14 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Genome-Wide Identification and Expression Analysis of the Aquaporin Gene Family in the Qinghai Toad-Headed Agama (Phrynocephalus vlangalii) and Responses to Acute Cold Stress

Biology
The aquaporin (AQP) gene family plays a critical role in water balance and osmotic regulation, yet its function and regulatory mechanisms in plateau reptiles remain poorly understood.
Yurong Zhang, Ping Yang, Xinyang Li, Jia Wang   +3 more
doaj   +1 more source

In Silico Genome-Wide Analysis of the Pear (Pyrus bretschneideri) KNOX Family and the Functional Characterization of PbKNOX1, an Arabidopsis BREVIPEDICELLUS Orthologue Gene, Involved in Cell Wall and Lignin Biosynthesis

Frontiers in Genetics, 2019
Stone cells are a characteristic trait of pear fruit, but the contents and sizes of stone cells negatively correlate with fruit texture and flavor.
Xi Cheng, Manli Li, Muhammad Abdullah, Guohui Li, Jingyun Zhang, Jingyun Zhang, Muhammad Aamir Manzoor, Han Wang, Qing Jin, Taoshan Jiang, Yongping Cai, Dahui Li, Yi Lin   +12 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Cross-species gene expression analysis of species specific differences in the preclinical assessment of pharmaceutical compounds

, 2014
Animals are frequently used as model systems for determination of safety and efficacy in pharmaceutical research and development. However, significant quantitative and qualitative differences exist between humans and the animal models used in research ...
Dzidzienyo, D, John Okyere, Sharma, L, Okyere, J, Oppon, E, Sharma Lav, Graham Ball, Ekow Oppon, Okyere John, Oppon Ekow, Daniel Dzidzienyo, Lav Sharma, Daniel Dzidzienyo (563466), Lav Sharma (563467), Ball, G, John Okyere (72708), Dzidzienyo Daniel, Ball Graham, Ekow Oppon (563465), Graham Ball (72613)   +19 more
core   +1 more source