Results 101 to 110 of about 4,331,351 (268)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Genome-wide investigation and expression analysis of sweet cherry PavNAC gene family under different abiotic stress

Frontiers in Plant Science
The NAC gene family is an important transcription factor unique to plants, widely involved in plant growth, development, and response to different stress.
Xiaomeng Shi, Xianyang Ai, Changping Tian, Aidi Zhang, Jianzhao Li, Jianzhao Li, Shuyang Sun   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Genome-Wide Analyses Reveal the Roles of CCT Genes as Regulators of Abiotic Stress Responses in Citrullus lanatus

Agronomy
Members of the CCT gene family have been shown to play roles in photoperiodic flowering and environmental adaptation under a range of conditions. In this study, 29 CCT genes from watermelon were categorized into three distinct subfamilies.
Yajie Hong, Mengsha Li, Wona Ding, Jun Shi, Zishuo Zheng, Nailin Xing, Qiuping Li   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Digital PCR-based gene expression analysis using a highly multiplexed assay with universal detection probes to study induced pluripotent stem cell differentiation into cranial neural crest cells

Induced pluripotent stem cells (iPSCs) have the potential to differentiate into any cell type, offering a valuable tool for research in developmental biology, regenerative medicine, and disease modeling.
Wils, GertjanGE31000171331201802003709577D78F0A64-AE06-11E7-9D2D-2D69AD28A064, Trypsteen, WimDI110020052664488020013056940000-0001-9066-49320E4509EA-F0EE-11E1-A9DE-61C894A0A6B4, Hamerlinck, LisaGE310001508720798020039002440000-0002-8210-2355D280312C-5419-11E5-8C8B-ACAEB4D1D7B1, Nour, Afif Abdel, Van Den Eeckhaut, Charlotte0001807016038FA98E30-A7E9-11E8-B8B0-BD545707D3EF, Weiss, Jonathan, Vergult, SarahGE310020030773798020004217820000-0002-0816-6262FB499586-F0ED-11E1-A9DE-61C894A0A6B4, Vandesompele, JoGE318010011883090000-0001-6274-0184F5540E9A-F0ED-11E1-A9DE-61C894A0A6B4   +7 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Genome-wide identification of the wall-associated kinase gene family and their expression patterns under various abiotic stresses in soybean (Glycine max (L.) Merr)

Frontiers in Plant Science
The wall-associated kinase (WAK) gene family encodes functional cell wall-related proteins. These genes are widely presented in plants and serve as the receptors of plant cell membranes, which perceive the external environment changes and activate ...
Xiangnan Li, Sifei Qi, Lingzhi Meng, Peisen Su, Yongwang Sun, Nan Li, Dan Wang, Yinglun Fan, Yong Song   +8 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source