Results 101 to 110 of about 29,337,137 (262)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Genome-Wide Identification and Expression Analysis of the Aquaporin Gene Family in the Qinghai Toad-Headed Agama (Phrynocephalus vlangalii) and Responses to Acute Cold Stress

Biology
The aquaporin (AQP) gene family plays a critical role in water balance and osmotic regulation, yet its function and regulatory mechanisms in plateau reptiles remain poorly understood.
Yurong Zhang, Ping Yang, Xinyang Li, Jia Wang   +3 more
doaj   +1 more source

In Silico Genome-Wide Analysis of the Pear (Pyrus bretschneideri) KNOX Family and the Functional Characterization of PbKNOX1, an Arabidopsis BREVIPEDICELLUS Orthologue Gene, Involved in Cell Wall and Lignin Biosynthesis

Frontiers in Genetics, 2019
Stone cells are a characteristic trait of pear fruit, but the contents and sizes of stone cells negatively correlate with fruit texture and flavor.
Xi Cheng, Manli Li, Muhammad Abdullah, Guohui Li, Jingyun Zhang, Jingyun Zhang, Muhammad Aamir Manzoor, Han Wang, Qing Jin, Taoshan Jiang, Yongping Cai, Dahui Li, Yi Lin   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Simcluster: clustering enumeration gene expression data on the simplex space [PDF]

, 2007
Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST "digital northern", are important high-throughput techniques for digital gene expression measurement.
de B Pereira Carlos A, Varuzza Leonardo, Shmulevich Ilya, Varuzza, Leonardo , Ricardo Z. N. Vêncio, Pereira, Carlos A de B, Carlos Pereira, Brentani, Helena , Vêncio Ricardo ZN, Ricardo Z. N. Vêncio, Brentani Helena, Helena Brentani, Shmulevich, Ilya , Leonardo A. B. Varuzza, Carlos A. De B. Pereira, Vêncio, Ricardo ZN, Ilya Shmulevich, Leonardo Varuzza, Carlos A de B Pereira, Ricardo ZN Vêncio   +19 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Genome-wide investigation and expression analysis of sweet cherry PavNAC gene family under different abiotic stress

Frontiers in Plant Science
The NAC gene family is an important transcription factor unique to plants, widely involved in plant growth, development, and response to different stress.
Xiaomeng Shi, Xianyang Ai, Changping Tian, Aidi Zhang, Jianzhao Li, Jianzhao Li, Shuyang Sun   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Molecular cloning, promoter analysis, and expression profile of VvERF3b gene in Vitis vinifera

, 2012
Ethylene response factors (ERFs) are involved in many plant development events and stress defenses. In this study, an ERF gene, VvERF3b, was cloned from the leaves of Vitis vinifera. VvERF3b belongs to ERF group VIIIa.
H. Hou, Y. Lin, Y. Song, S. Tong
core   +1 more source

Genome-Wide Analyses Reveal the Roles of CCT Genes as Regulators of Abiotic Stress Responses in Citrullus lanatus

Agronomy
Members of the CCT gene family have been shown to play roles in photoperiodic flowering and environmental adaptation under a range of conditions. In this study, 29 CCT genes from watermelon were categorized into three distinct subfamilies.
Yajie Hong, Mengsha Li, Wona Ding, Jun Shi, Zishuo Zheng, Nailin Xing, Qiuping Li   +6 more
doaj   +1 more source