Results 121 to 130 of about 28,109,296 (301)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Genome-Wide Analyses Reveal the Roles of CCT Genes as Regulators of Abiotic Stress Responses in Citrullus lanatus

Agronomy
Members of the CCT gene family have been shown to play roles in photoperiodic flowering and environmental adaptation under a range of conditions. In this study, 29 CCT genes from watermelon were categorized into three distinct subfamilies.
Yajie Hong, Mengsha Li, Wona Ding, Jun Shi, Zishuo Zheng, Nailin Xing, Qiuping Li   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Gene Expression Analysis Methods on Microarray Data a A Review [PDF]

, 2014
In recent years a new type of experiments are changing the way that biologists and other specialists analyze many problems. These are called high throughput experiments and the main difference with those that were performed some years ago is mainly in ...
Prof G V Padma Raju
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Digital PCR-based gene expression analysis using a highly multiplexed assay with universal detection probes to study induced pluripotent stem cell differentiation into cranial neural crest cells

Induced pluripotent stem cells (iPSCs) have the potential to differentiate into any cell type, offering a valuable tool for research in developmental biology, regenerative medicine, and disease modeling.
Wils, GertjanGE31000171331201802003709577D78F0A64-AE06-11E7-9D2D-2D69AD28A064, Trypsteen, WimDI110020052664488020013056940000-0001-9066-49320E4509EA-F0EE-11E1-A9DE-61C894A0A6B4, Hamerlinck, LisaGE310001508720798020039002440000-0002-8210-2355D280312C-5419-11E5-8C8B-ACAEB4D1D7B1, Nour, Afif Abdel, Van Den Eeckhaut, Charlotte0001807016038FA98E30-A7E9-11E8-B8B0-BD545707D3EF, Weiss, Jonathan, Vergult, SarahGE310020030773798020004217820000-0002-0816-6262FB499586-F0ED-11E1-A9DE-61C894A0A6B4, Vandesompele, JoGE318010011883090000-0001-6274-0184F5540E9A-F0ED-11E1-A9DE-61C894A0A6B4   +7 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Genome-wide identification of the wall-associated kinase gene family and their expression patterns under various abiotic stresses in soybean (Glycine max (L.) Merr)

Frontiers in Plant Science
The wall-associated kinase (WAK) gene family encodes functional cell wall-related proteins. These genes are widely presented in plants and serve as the receptors of plant cell membranes, which perceive the external environment changes and activate ...
Xiangnan Li, Sifei Qi, Lingzhi Meng, Peisen Su, Yongwang Sun, Nan Li, Dan Wang, Yinglun Fan, Yong Song   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source