Results 171 to 180 of about 234,285 (301)

Nuclear Quantum Effects on the Equation of State of Water: Insights from the Potential Energy Landscape Formalism. [PDF]

J Chem Theory Comput
Eltareb A, Lopez GE, Giovambattista N.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

From gene correlations to cell clusters: COTAN improved scRNA-seq analysis. [PDF]

NAR Genom Bioinform
Galfrè SG, Fantozzi M, Sîrbu A, Testa I, Tolloso M, Alberti A, Priami C, Morandin F.   +7 more
europepmc   +1 more source

Emphatic agents to reduce user frustration: The effects of varying agent characteristics

, 2006
There is now growing interest in the development of computer systems which respond to users’ emotion and affect. We report three small scale studies (with a total of 42 participants) which investigate the extent to which affective agents, using ...
Hone, KS
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Histology-informed spatial domain identification through multi-view graph convolutional networks. [PDF]

PLoS Comput Biol
Zhang H, Chang J, Li Z, Sun Y, Hu P, Wang H, Yang H, Ren Y, Zhang X, Chen Z, Wong KW, Shao H.   +11 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

STGNET: extending panel coverage in imaging-based spatial transcriptomics using deep generative adversarial networks. [PDF]

Brief Bioinform
Wang T, Wang B, Shu H, Zhen P, Hu J, Wang Y, Peng J, Shang X, Wu Z, Xiao B, Chen J.   +10 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

AFP Stimulates Glucose Metabolic Reprogramming Contributing to Hepatocellular Carcinoma Resist Sorafenib Through Activating PI3K/AKT Signalling Pathway. [PDF]

J Cell Mol Med
Zhou Y, Feng S, Chen Y, Lin B, Li W, Dong X, Liu K, Yin Q, Li M, Zhu M.   +9 more
europepmc   +1 more source