Results 221 to 230 of about 1,325,838 (268)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Multi-visual pattern mining algorithm based on variational inference Gaussian mixture and pattern activation response map model. [PDF]

PLoS One
Zhang Z, Chen P, Liu Y, He Y.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Robust regression rescues poor phylogenetic decisions. [PDF]

BMC Ecol Evol
Duncan M, DeGiorgio M, Assis R, Adams R.
europepmc   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Teaching the laboratory assessment of neutrophil chemotaxis: a simulation-based approach for undergraduate immunology. [PDF]

Immunohorizons
Costabile M, Denyer G.
europepmc   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

An open-source software for building and simulating ordinary differential equation models in biology. [PDF]

PLoS One
Dos Santos BLM, Castro DAS, da Paz SFC, Pinheiro DJC, de Melo Quintela B, Lobosco M, Pigozzo AB.   +6 more
europepmc   +1 more source

Enhancing and accelerating cell type deconvolution of large-scale spatial transcriptomics slices with dual network model. [PDF]

Bioinformatics
Zha Y, Feng S, Gao P, Zou Q, Ma X.
europepmc   +1 more source

A Public Health Approach to Automated Pain Intensity Recognition in Chest Pain Patients via Facial Expression Analysis for Emergency Care Prioritization. [PDF]

Diagnostics (Basel)
Wiryasaputra R, Tsan YT, Zhang QX, Liu HH, Chan YW, Yang CT.   +5 more
europepmc   +1 more source