Results 261 to 270 of about 2,116,656 (327)

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Dynamic Visualization of Computer-Aided Peptide Design for Cancer Therapeutics. [PDF]

Drug Des Devel Ther
Hou D, Zhou H, Tang Y, Liu Z, Su L, Guo J, Pathak JL, Wu L.   +7 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

<i>k</i>-mer manifold approximation and projection for visualizing DNA sequences. [PDF]

Genome Res
Fu C, Niskanen EA, Wei GH, Yang Z, Sanvicente-García M, Güell M, Cheng L.   +6 more
europepmc   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Application of Multiple Deep Learning Architectures for Emotion Classification Based on Facial Expressions. [PDF]

Sensors (Basel)
Qian C, Lobo Marques JA, de Alexandria AR, Fong SJ.   +3 more
europepmc   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Theoretical Simulation of Output Characteristics of an RTD-Fluxgate Sensor Under Sawtooth Wave Excitation. [PDF]

Micromachines (Basel)
Guo H, Pang N, Hu X, Wang R, Li G, Li F.
europepmc   +1 more source

Presumptive Tests for Xylazine-A Computer Vision Approach. [PDF]

Anal Sci Adv
Chang HY, Donnachie K, McCabe TJD, Barrington H, Carlysle-Davies F, Ceniccola-Campos K, Reid M.   +6 more
europepmc   +1 more source

Utilisation of Deep Neural Networks for Estimation of Cajal Cells in the Anal Canal Wall of Patients with Advanced Haemorrhoidal Disease Treated by LigaSure Surgery. [PDF]

Cells
Fišere I, Edelmers E, Svirskis Š, Groma V.   +3 more
europepmc   +1 more source