Results 181 to 190 of about 31,723,480 (301)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Early vs late fusion of qMIDS with machine learning based classifiers for oral cancer diagnosis from gene expression data. [PDF]

PLoS Comput Biol
Ben Ali F, Mporas I, Balaji V, Ibaranyanakaye D, Carey B, Teh MT, Adeleke S.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Improved prognostic survival models for pediatric medulloblastoma using high dimensional gene expression data. [PDF]

BMC Med Genomics
Amona EB, Sumy MSA, Jones T, Wang S, Mistry AM, Raj A, Donninger H, Yaddanapudi K, Kong M.   +8 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Cis-TERN: a graph-based method to integrate single-cell chromatin accessibility with gene expression data to infer the pseudotime ordering of cells. [PDF]

Bioinform Adv
Gokhale A, Przytycki PF.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Normalization of nCounter Gene Expression Data Alters Molecular Diagnostics in Kidney Transplantation. [PDF]

J Am Soc Nephrol
Piedrafita A, Sablik M, Preka E, Goutaudier V, Demir Z, Mezine F, Divard G, Dagobert J, Robin B, Truchot A, Thalamas T, Sannier A, Rabant M, Aubert O, Maanaoui M, Le Quintrec M, Couzi L, Chauveau B, Bestard O, Elias M, Louis K, Rosales IA, Smith RN, Anglicheau D, Del Bello A, Budde K, Halleck F, Huang E, Adam B, Villard J, Kamar N, Lefaucheur C, Colvin RB, Mengel M, Loupy A.   +34 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Statistical Visibility of Curated TF-Target Regulatory Relationships and Reverse Consistency of Top-Ranked TF-Gene Pairs in Single-Cell Expression Data. [PDF]

Genes (Basel)
Feng W, Zhang Z, Wu Z, Yuan C, Sun J, Wang G, Liu Y.   +6 more
europepmc   +1 more source