Results 11 to 20 of about 327,732 (266)
Optimizing stringency for expression microarrays [PDF]
BioTechniques, 2003 While several studies have reported methods to optimize expression microarray protocols, none have dealt directly with hybridization wash stringency. We designed a series of experiments to determine the optimal stringency conditions for microarray experiments, using reproducibility and magnitudes of log2 (test/reference) ratio values as measures of ...
James E. Korkola +5 more
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Optimizing package express operations in China
European Journal of Operational Research, 2022 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Baris Yildiz 0001 +1 more
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Optimizing the dynamics of protein expression [PDF]
Scientific Reports, 2019 AbstractHeterologously expressed genes require adaptation to the host organism to ensure adequate levels of protein synthesis, which is typically approached by replacing codons by the target organism’s preferred codons. In view of frequently encountered suboptimal outcomes we introduce the codon-specific elongation model (COSEM) as an alternative ...
Jan-Hendrik Trösemeier +9 more
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Optimization of gene expression by natural selection [PDF]
Proceedings of the National Academy of Sciences, 2009 It is generally assumed that stabilizing selection promoting a phenotypic optimum acts to shape variation in quantitative traits across individuals and species. Although gene expression represents an intensively studied molecular phenotype, the extent to which stabilizing selection limits divergence in gene expression remains ...
Bedford, Trevor, Hartl, Daniel
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Strategies for Optimizing the Production of Proteins and Peptides with Multiple Disulfide Bonds
Antibiotics, 2020 Bacteria can produce recombinant proteins quickly and cost effectively. However, their physiological properties limit their use for the production of proteins in their native form, especially polypeptides that are subjected to major post-translational ...
Yunqi Ma, Chang-Joo Lee, Jang-Su Park
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Regression-Based Facial Expression Optimization [PDF]
IEEE Transactions on Human-Machine Systems, 2014 This paper presents an approach for reproducing optimal 3-D facial expressions based on blendshape regression. It aims to improve fidelity of facial expressions but maintain the efficiency of the blendshape method, which is necessary for applications such as human–machine interaction and avatars.
Hui Yu 0001, Honghai Liu 0001
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Optimized expression of alternative oxidase
Gene Therapy, 2022 In their paper titled “Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active” Giordano et al. [1] report on a very interesting paradigm that concerns mitochondrial function.
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Vector Design for Optimal Protein Expression [PDF]
BioTechniques, 2001 Many DNA constructs are generated for protein expression studies. Translational properties and mRNA stability are crucial aspects that have to be accounted for during DNA construction. An optimized vector for protein overexpression studies is described considering elements in the mature mRNA that influence translatability and stability. Recommendations
van der Velden, A.W. +2 more
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Optimizing Expression of a Llama-Based Anti-PSMA Nanobody in Escherichia Coli and Its Application in Immunohistochemistry of Prostate Cancer Tissues [PDF]
Advanced Pharmaceutical BulletinPurpose: Nanobodies possess unique properties that make them promising as tumor targeting agents. Prostate-specific membrane antigen (PSMA), overexpressed in prostate cancer, can be an excellent target for prostate cancer diagnosis.
Seyedeh Sheila Seyed-Motahari +4 more
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Optimal Regular Expressions for Permutations
CoRR, 2018 The permutation language $P_n$ consists of all words that are permutations of a fixed alphabet of size $n$. Using divide-and-conquer, we construct a regular expression $R_n$ that specifies $P_n$. We then give explicit bounds for the length of $R_n$, which we find to be $4^n n^{-(\lg n)/4+Θ(1)}$, and use these bounds to show that $R_n$ has minimum size ...
Antonio Molina Lovett +1 more
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