Results 71 to 80 of about 12,102,695 (290)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Target of Rapamycin (TOR) Regulates the Expression of lncRNAs in Response to Abiotic Stresses in Cotton

Frontiers in Genetics, 2019
TOR (Target of Rapamycin) kinase is an evolutionarily conserved protein kinase, which integrates stress-related cues with growth and metabolic outputs. Long non-coding RNAs (lncRNAs) play a vital role in the regulation of eukaryotic genes.
Yun Song, Yun Song, Linxuan Li, Zhaoen Yang, Zhaoen Yang, Ge Zhao, Ge Zhao, Xueyan Zhang, Xueyan Zhang, Lingling Wang, Lingling Wang, Lei Zheng, Lei Zheng, Fengping Zhuo, Huan Yin, Xiaoyang Ge, Xiaoyang Ge, Chaojun Zhang, Chaojun Zhang, Zuoren Yang, Zuoren Yang, Maozhi Ren, Fuguang Li, Fuguang Li   +23 more
doaj   +1 more source

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

Journal of Experimental Medicine, 1997
Chemokine receptors serve as coreceptors for HIV entry into CD4+ cells. Their expression is thought to determine the tropism of viral strains for different cell types, and also to influence susceptibility to infection and rates of disease progression. Of
Lijun Wu, W. Paxton, N. Kassam, N. Ruffing, J. Rottman, N. Sullivan, H. Choe, J. Sodroski, W. Newman, R. Koup, C. Mackay   +10 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A novel DREB transcription factor from Halimodendron halodendron leads to enhance drought and salt tolerance in Arabidopsis

Biologia Plantarum, 2015
A new member of the APETALA2/ethylene responsive element binding protein (AP2/EREBP) transcription factor family, HhDREB2, was isolated from Halimodendron halodendron.
J. -T. Ma, C. -C. Yin, Q. -Q. Guo, M. -L. Zhou, Z. -L. Wang, Y. -M. Wu   +5 more
doaj   +1 more source

Gene expression patterns in human placenta [PDF]

Proceedings of the National Academy of Sciences, 2006
The placenta is the principal metabolic, respiratory, excretory, and endocrine organ for the first 9 months of fetal life. Its role in fetal and maternal physiology is remarkably diverse. Because of the central role that the placenta has in fetal and maternal physiology and development, the possibility that variation in placental gene expression ...
Ruchira, Sood, James L, Zehnder, Maurice L, Druzin, Patrick O, Brown   +3 more
openaire   +2 more sources

Identification of a Common Lupus Disease-Associated microRNA Expression Pattern in Three Different Murine Models of Lupus

PLoS ONE, 2010
Background Recent reports have shown that microRNAs (miRNAs) regulate vital immunological processes and have emerged as key regulators of immune system development and function.
R. Dai, Yan Zhang, D. Khan, B. Heid, D. Caudell, O. Crasta, S. Ahmed   +6 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Expressing Adaptation Strategies Using Adaptation Patterns

IEEE Transactions on Learning Technologies, 2012
Today, there is a real challenge to enable personalized access to information. Several systems have been proposed to address this challenge including Adaptive Hypermedia Systems (AHSs). How- ever, the specification of adaptation strategies remains a difficult task for creators of such systems. In this paper, we consider the problem of the definition of
Zemirline, Nadjet, Bourda, Yolaine, Reynaud, Chantal   +2 more
openaire   +3 more sources