Results 291 to 300 of about 12,776,966 (376)

Altered Co-Expression Patterns of Mitochondrial NADH-Dehydrogenase Genes in the Prefrontal Cortex of Rodent ADHD Models. [PDF]

Int J Mol Sci
Sylko PA, Gromova AA, Fesenko ZS, Kanov EV, Volnova AB, Gainetdinov RR, Vaganova AN.   +6 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Elucidating the role of <i>SHROOM4</i> in non-small cell lung cancer: expression patterns, clinical correlations, and potential functions. [PDF]

Front Immunol
Zhang Y, Qiang R, Ding M, Wang L.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Analysis of the chitin synthase gene family in <i>Ganoderma lucidum</i>: its structure, phylogeny, and expression patterns. [PDF]

PeerJ
Liu L, Yang Y, Li J, Gao Y, Yan M.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

PAX3 expression patterns in ocular surface melanocytes. [PDF]

Sci Rep
Ulrich E, Kistenmacher S, Martin G, Schlötzer-Schrehardt U, Seitz B, Auw-Hädrich C, Schlunck G, Reinhard T, Polisetti N.   +8 more
europepmc   +1 more source

Deciphering regulatory architectures of bacterial promoters from synthetic expression patterns

Rosalind Wenshan Pan, Tom Röschinger, Kian Faizi, Hernán G. García, Rob Phillips   +4 more
openalex   +1 more source

Integrin Expression in Esophageal Squamous Cell Carcinoma: Loss of the Physiological Integrin Expression Pattern Correlates with Disease Progression

, 2014
Christian Vay, Stefan B. Hosch, Nikolas H. Stoecklein, Christoph A. Klein, Daniel Vallböhmer, Björn‐Christian Link, Emre F. Yekebas, Jakob R. Izbicki, Wolfram Trudo Knoefel, P. Scheunemann   +9 more
openalex   +2 more sources