Results 71 to 80 of about 12,776,966 (376)

Finding the center reliably: robust patterns of developmental gene expression

, 2005
We investigate a mechanism for the robust identification of the center of a developing biological system. We assume the existence of two morphogen gradients, an activator emanating from the anterior, and a co-repressor from the posterior.
A. Eldar, A. M. Turing, A. V. Spirov, B. Houchmandzadeh, C. Zhao, H. Meinhardt, L. Wolpert, Martin Howard, Pieter Rein ten Wolde, X. Ma   +9 more
core   +1 more source

TCL1 expression patterns in Waldenström macroglobulinemia [PDF]

Modern Pathology, 2016
The oncogenic role of TCL1 in chronic lymphocytic leukemia is well established in transgenic mice. TCL1 expression in other B-cell malignancies has been also described: post-germinal center-derived malignancies, such as multiple myeloma, classically do not express TCL1. Waldenström macroglobulinemia is a post-germinal center malignancy that is known to
Richard, Lemal, Sandrine, Bard-Sorel, Laura, Montrieul, Jacques-Olivier, Bay, Aurélie, Ravinet, Albane, Ledoux-Pilon, Nicolas, Cagnard, Sébastien, Bailly, Pierre, Morel, Frédéric, Charlotte, Xavier, Leleu, Stéphanie, Poulain, Pierre J, Déchelotte, Olivier, Hermine, Véronique, Leblond, Olivier, Tournilhac, Romain, Guièze   +16 more
openaire   +2 more sources

Oncogenic NRAS Mutation in Incipient Sarcomatous Transformation of Cystic Nephroma From a Patient With DICER1‐Related Tumor Predisposition Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Anaplastic sarcoma of the kidney (ASK) is a DICER1‐associated malignant tumor presumed to arise in a benign precursor, pediatric cystic nephroma (PCN). However, the initial oncogenic alteration(s) associated with malignant transformation are unknown.
Nahir Cortes‐Santiago, Sarah B. Whittle, Sarah Scollon, Sharon E. Plon, Sanjeev Vasudevan, Bryony J. Lucas, Angshumoy Roy   +6 more
wiley   +1 more source

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers [PDF]

, 2012
Background: Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET).
Agostinelli, Claudio, Bergmann, Lothar, Diener, Jürgen, Döring, Claudia, Fanti, Stefano, Gallamini, Andrea, Hansmann, Martin-Leo, Hartmann, Sylvia, Pileri, Stefano, Zinzani, Pier Luigi   +9 more
core   +1 more source

GEPS: the Gene Expression Pattern Scanner [PDF]

Nucleic Acids Research, 2006
Gene Expression Pattern Scanner (GEPS) is a web-based server to provide interactive pattern analysis of user-submitted microarray data for facilitating their further interpretation. Putative gene expression patterns such as correlated expression, similar expression and specific expression are determined globally and systematically using geometric ...
Wang, Yu-Peng, Liang, Liang, Han, Bu-Cong, Quan, Yu, Wang, Xiao, Tao, Tao, Ji, Zhi-Liang   +6 more
openaire   +3 more sources

Polyclonal CD4+ T cell tolerance is established by distinct mechanisms, according to self-peptide expression patterns

Nature Immunology, 2015
Studies of repertoires of mouse monoclonal CD4+ T cells have revealed several mechanisms of self-tolerance; however, which mechanisms operate in normal repertoires is unclear. Here we studied polyclonal CD4+ T cells specific for green fluorescent protein
D. Malhotra, Jonathan L. Linehan, T. Dileepan, You Jeong Lee, Whitney E. Purtha, Jennifer Lu, Ryan W. Nelson, B. Fife, H. Orr, Mark S. Anderson, K. Hogquist, M. Jenkins   +11 more
semanticscholar   +1 more source

What to Do When Medical Evidence Can Only Be Generated Through Routine Data: An Example From Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children undergoing allogeneic stem cell transplantation often receive off‐label rituximab treatment for Epstein–Barr virus reactivation, using adult dosing without pediatric evidence. This project aims to develop a clinical decision support tool (CDSS) that provides evidence‐based dosing scenarios by analyzing real‐world patient data.
Birgit Burkhardt, Antje Walz, Dietrich Knoerzer   +2 more
wiley   +1 more source

Genome-Wide Identification and Characterization of Receptor-Like Protein Kinase 1 (RPK1) Gene Family in Triticum aestivum Under Drought Stress

Frontiers in Genetics, 2022
Receptor-like protein kinase1 (RPK1) genes play crucial roles in plant growth and development processes, root architecture, and abiotic stress regulation.
Amna Abdul Rahim, Amna Abdul Rahim, Muhammad Uzair, Nazia Rehman, Obaid Ur Rehman, Nageen Zahra, Muhammad Ramzan Khan, Muhammad Ramzan Khan   +7 more
doaj   +1 more source

Temporal patterns of gene expression via nonmetric multidimensional scaling analysis

, 2003
Motivation: Microarray experiments result in large scale data sets that require extensive mining and refining to extract useful information. We have been developing an efficient novel algorithm for nonmetric multidimensional scaling (nMDS) analysis for ...
Cho, Eisen, Iyer, Johansson, Kanaya, Kasturi, Shmulevich, Spellman, Y. Oono, Y.-h. Taguchi   +9 more
core   +2 more sources

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source