Results 121 to 130 of about 6,393,379 (315)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Gene expression profile using young HDF donors as the control.
, 2019 Gene expression profile using young HDF donors as the control.
Juliana Carvalhães Lago (317685) +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Gene expression profile of the primary catecholaminergic markers after differentiation.
, 2015 Gene expression profile of the primary catecholaminergic markers after differentiation.
Luigi Bubacco (83582) +7 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Gene expression profile of stemness markers.
, 2014 Gene expression profile of stemness markers in the LDL (white bars), MDL (grey bars), and HDL (black bars). The results are reported as ratios (R) with respect to the mRNA expression levels of non-centrifuged fat (not shown).
Luigi Clauser (655709) +9 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Ascidian gene-expression profiles.
Genome biology, 2002 With the advent of gene-expression profiling, a large number of genes can now be investigated simultaneously during critical stages of development. This approach will be particularly informative in studies of ascidians, basal chordates whose genomes and embryology are uniquely suited for mapping developmental gene networks.
openaire +3 more sources
Expression profile of PtSultr3;5.
, 2012 (A) Expression pattern of PtSultr3;5 (Poptr_0006s16150) assessed by oligoarray, RT-qPCR and RNA-Seq. RNA-Seq and RT-qPCR values are Ln-transformed. For RNA-Seq, both results from the contig-blast (cb) and the read-mapping (rm) methods are presented ...
Francis Martin (44535) +10 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source