Results 141 to 150 of about 6,393,379 (315)

Profile of ALG-1 and ALG-2 expression in larval stage.

, 2012
Expression profile of GFP::ALG-2 and RFP::ALG-1 as seen in the L1 larval stage. Subsequent larval stages (L2 to L4) and adults display the same expression profile (not shown). Scale bar 20 µm.
Evelyne L. Rondeau (177862), Javier Armisen (20156), Syed Irfan Ahmad Bukhari (86732), Guillaume Jannot (177849), Michel Labouesse (177857), Alejandro Vasquez-Rifo (177846), Eric A. Miska (41828), Martin J. Simard (109555)   +7 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Changes in gene expression of the TNFα profile.

, 2012
Heat map of normalised expression levels (average intensity) of the 198 genes in the TNFα profile under the 8 treatment conditions.
Oxana Polyakova (112157), Andrew Fosberry (153144), Bernadette Mouzon (153152), Nicola Richmond (153161), Roberto Solari (112167), Joanne McKenary (153128), Nathalie Barrett (153158), Brian Hayes (112164), Sundip Modha (153164), Chun-Wa Chung (153155), Champa Patel (153135), Anshu Bhardwaja (153148), Rachel Grimley (112160), Jessica Vamathevan (2825), Angela Bridges (153140), Janet Smith (54931)   +15 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Differences in global miRNA expression profile.

, 2012
Differences related to A) allopolyplodization and B) hybridization. C) Differential expression profile between the parental species. Logarithmized ratios of gene expression for each miRNA were plotted producing a characteristic crescent curve where ...
Maria Manuela Coelho (150375), Angela Inácio (150357), Patrícia Matos Pereira (150368), Luca Comai (13000), Joana Pinho (150362)   +4 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Hepatic gene expression profile in the neonatal offspring.

, 2013
Heatmap with hierarchical clustering of the hepatic gene expression profile of 4-day old offspring (n = 3 in each group).
Anna-Maija Penttinen (282524), Liisa Ailanen (282525), Henriikka Salomäki (282521), Kirsti Laurila (219690), Ullamari Pesonen (282527), Juan Ilyasizadeh (282526), Markku Koulu (282528), Laura H. Vähätalo (282522), Norma T. Jäppinen (282523)   +8 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source