GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Promoting psychological crisis coping through physical activity: The mediating roles of rumination and emotion regulation among college students. [PDF]
PLoS OneYang Y, Lu B, Wang S.
europepmc +1 more source
Associations between physical activity and sleep quality among college students: the chain-mediating roles of rumination and emotion regulation strategies. [PDF]
Front PsycholGu Y +5 more
europepmc +1 more source
Attachment, Emotional Regulation, and Perceived Academic Efficacy in Adolescence: A Basis for Psychoeducational Intervention. [PDF]
Psychosoc IntervDoménech P +2 more
europepmc +1 more source
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The social consequences of expressive suppression.
Emotion, 2003At times, people keep their emotions from showing during social interactions. The authors' analysis suggests that such expressive suppression should disrupt communication and increase stress levels. To test this hypothesis, the authors conducted 2 studies in which unacquainted pairs of women discussed an upsetting topic.
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Based on an interview study of neonatal nurses, this article sets out to explore the management of emotions within a work context where their suppression is a professional requirement. Drawing on Bolton’s (2000a, 2000b) identification of different types of organizational emotionality, in particular prescriptive and philanthropic emotion management, the
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Expressive suppression during an acoustic startle
Psychophysiology, 2006AbstractPrevious studies have shown that inhibiting negative or positive emotion‐expressive behavior leads to increased sympathetic activation. Inhibiting facial behavior while in an affectively neutral state has no such physiological consequences. This suggests that there may be something special about inhibiting emotion‐expressive behavior.
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