Results 31 to 40 of about 64,799 (296)

Parkin Suppresses the Expression of Monoamine Oxidases [PDF]

Journal of Biological Chemistry, 2006
Mutations of parkin are linked to early onset Parkinson disease. Here we show that stable transfection of parkin in the human dopaminergic neuroblastoma cell line SH-SY5Y markedly reduced the activities of both monoamine oxidase (MAO) A and B. The amount of 3,4-dihydroxyphenylacetic acid, which is produced during dopamine oxidation by MAO, was greatly ...
Houbo, Jiang, Qian, Jiang, Wenhua, Liu, Jian, Feng   +3 more
openaire   +2 more sources

Coherence between subjective experience and physiology in emotion: Individual differences and implications for well-being. [PDF]

, 2020
Emotion theorists have characterized emotions as involving coherent responding across various emotion response systems (e.g., covariation of subjective experience and physiology). Greater response system coherence has been theorized to promote well-being,
Brown, Casey L, Ford, Brett Q, Levenson, Robert W, Mauss, Iris B, Sze, Jocelyn W, Van Doren, Natalia   +5 more
core  

Hanging With the Wrong Crowd: Of Gangs, Terrorists, and the Right of Association [PDF]

, 1999
Part I will sketch the current contours of the right of association, a right limited to expressive and intimate association, and will describe the government\u27s attempts to extend this categorical approach by limiting associational protection still
Cole, David
core   +2 more sources

Human cytomegalovirus suppresses Fas expression and function [PDF]

Journal of General Virology, 2014
Human cytomegalovirus (HCMV) is known to evade extrinsic pro-apoptotic pathways not only by downregulating cell surface expression of the death receptors TNFR1, TRAIL receptor 1 (TNFRSF10A) and TRAIL receptor 2 (TNFRSF10B), but also by impeding downstream signalling events.
Seirafian, Sepher, Prod'homme, Virginie, Sugrue, Daniel, Davies, James, Fielding, Ceri, Tomasec, Peter, Wilkinson, Gavin W. G.   +6 more
openaire   +2 more sources

Infants' mu suppression during the observation of real and mimicked goal-directed actions [PDF]

, 2012
Since their discovery in the early 1990s, mirror neurons have been proposed to be related to many social-communicative abilities, such as imitation. However, research into the early manifestations of the putative neural mirroring system and its role in ...
Handl, A, Pattyn, Griet, Roeyers, Herbert, Ruysschaert, Lieselot, Warreyn, Petra, Wiersema, Roeljan   +5 more
core   +1 more source

Estrogen suppresses adipogenesis by inhibiting S100A16 expression [PDF]

Journal of Molecular Endocrinology, 2014
The aim of this study is to determine the effects of E2 on metabolic syndrome and the molecular mechanisms involving S100A16. Ovariectomized (OVX) rat models and mouse embryonic fibroblasts cell models were used. E2 loss in OVX rats induced body weight gain and central abdominal fat accumulation, which were ameliorated by E2 treatment under chow and ...
Zhang, Rihua, Su, Dongming, Zhu, Weidong, Huang, Qiong, Liu, Menglan, Xue, Yi, Zhang, Yuanyuan, li, Dong, Zhao, Allan, Liu, Yun   +9 more
openaire   +2 more sources

Inflammation suppresses DLG2 expression decreasing inflammasome formation

Journal of Cancer Research and Clinical Oncology, 2022
Abstract Purpose Loss of expression of DLG2 has been identified in a number of cancers to contribute to the disease by resulting in increased tumor cell proliferation and poor survival. In light of the previous evidence that DLG2 alters the cell cycle and affects proliferation, combined with indications that DLG2 is ...
Simon Keane, Matthew Herring, Peter Rolny, Yvonne Wettergren, Katarina Ejeskär   +4 more
openaire   +3 more sources

Imatinib and spironolactone suppress hepcidin expression

Haematologica, 2017
Disorders of iron metabolism are largely attributed to an excessive or insufficient expression of hepcidin, the master regulator of systemic iron homeostasis. Here, we investigated whether drugs targeting genetic regulators of hepcidin can affect iron homeostasis.
Mleczko-Sanecka, Katarzyna, da Silva, Ana Rita, Call, Debora, Neves, Joana, Schmeer, Nikolai, Damm, Georg, Seehofer, Daniel, Muckenthaler, Martina U.   +7 more
openaire   +3 more sources

YAP suppresses gluconeogenic gene expression through PGC1α [PDF]

Hepatology, 2017
Cell growth and proliferation are tightly coupled to metabolism, and dissecting the signaling molecules which link these processes is an important step toward understanding development, regeneration, and cancer. The transcriptional regulator Yes‐associated protein 1 (YAP) is a key regulator of liver size, development, and function. We now show that YAP
Yue, Hu, Dong-Ju, Shin, Hui, Pan, Zhiqiang, Lin, Jonathan M, Dreyfuss, Fernando D, Camargo, Ji, Miao, Sudha B, Biddinger   +7 more
openaire   +2 more sources

Terrorizing Advocacy and the First Amendment: Free Expression and the Fallacy of Mutual Exclusivity [PDF]

, 2017
Traditional free speech doctrine is inadequate to account for modern terrorist speech. Unprotected threats and substantially protected lawful advocacy are not mutually exclusive.
Fisher, Matthew, Redish, Martin H.
core   +2 more sources