Results 51 to 60 of about 7,978 (249)

Translational Suppression in Retroviral GENE Expression

, 1992
This chapter summarizes the present state of knowledge concerning translational suppression in retroviruses. Other viruses, using similar mechanisms, are mentioned only briefly and tangentially. Retroviruses are a unique class of viruses that have been found in all classes of vertebrates but not in other organisms.
Hatfield, Dolph L., Levin, Judith G., Rein, Alan, Oroszlan, Stephen   +3 more
openaire   +2 more sources

MicroRNA-33 suppresses CCL2 expression in chondrocytes [PDF]

Bioscience Reports, 2016
CCL2-mediated macrophage infiltration in articular tissues plays a pivotal role in the development of the osteoarthritis (OA). miRNAs regulate the onset and progression of diseases via controlling the expression of a series of genes. How the CCL2 gene was regulated by miRNAs was still not fully elucidated. In the present study, we demonstrated that the
Wei, Meng, Xie, Qingyun, Zhu, Jun, Wang, Tao, Zhang, Fan, Cheng, Yue, Guo, Dongyang, Wang, Ying, Mo, Liweng, Wang, Shuai   +9 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Suppression of Antimicrobial Peptide Expression by Ureaplasma Species [PDF]

Infection and Immunity, 2014
ABSTRACT Ureaplasma species commonly colonize the adult urogenital tract and are implicated in invasive diseases of adults and neonates. Factors that permit the organisms to cause chronic colonization or infection are poorly understood.
Li, Xiao, Donna M, Crabb, Yuling, Dai, Yuying, Chen, Ken B, Waites, T Prescott, Atkinson   +5 more
openaire   +2 more sources

Physical activity and academic burnout among middle school students: uncovering cognitive reappraisal and expressive suppression

Frontiers in Psychology
ObjectiveThis study examined whether cognitive reappraisal and expressive suppression mediate the association between physical activity and academic burnout among students at Huaihua Experimental Junior High School.MethodsA cross-sectional study was ...
Jiaxi Chen, Linghui Zou, Ziping Fan, Xiu Feng, Xinbo Wu, Dianhui Peng, Weixin Dong, Chunxia Lu, Jun Chen   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Human cytomegalovirus suppresses Fas expression and function [PDF]

Journal of General Virology, 2014
Human cytomegalovirus (HCMV) is known to evade extrinsic pro-apoptotic pathways not only by downregulating cell surface expression of the death receptors TNFR1, TRAIL receptor 1 (TNFRSF10A) and TRAIL receptor 2 (TNFRSF10B), but also by impeding downstream signalling events.
Seirafian, Sepher, Prod'homme, Virginie, Sugrue, Daniel, Davies, James, Fielding, Ceri, Tomasec, Peter, Wilkinson, Gavin W. G.   +6 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Estrogen suppresses adipogenesis by inhibiting S100A16 expression [PDF]

Journal of Molecular Endocrinology, 2014
The aim of this study is to determine the effects of E2 on metabolic syndrome and the molecular mechanisms involving S100A16. Ovariectomized (OVX) rat models and mouse embryonic fibroblasts cell models were used. E2 loss in OVX rats induced body weight gain and central abdominal fat accumulation, which were ameliorated by E2 treatment under chow and ...
Zhang, Rihua, Su, Dongming, Zhu, Weidong, Huang, Qiong, Liu, Menglan, Xue, Yi, Zhang, Yuanyuan, li, Dong, Zhao, Allan, Liu, Yun   +9 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source