Results 61 to 70 of about 7,954 (252)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The effects of sexual shame, emotion regulation and gender on sexual desire

Scientific Reports, 2023
Sexual desire is of importance to sexual health, functioning, and well-being. Although an increasing number of studies address disorders related to sexual functioning, there is still a limited understanding of the underlying individual factors affecting ...
K. W. Sævik, C. Konijnenberg
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Emotion Regulation Strategies and Social Media Addiction: Gender-Specific Pathways Through Social Anxiety and Depression in Youth

Human Behavior and Emerging Technologies
The increasing prevalence of social media addiction (SMA) among adolescents poses significant challenges for mental health, highlighting the need for effective prevention and intervention strategies.
Lucia Monacis, Daiana Colledani, Claudia Mortali, Pasquale Anselmi, Luis J. Gomez Perez, Bruno Genetti, Daniele Fassinato, Luisa Mastrobattista, Adele Minutillo   +8 more
doaj   +1 more source

Modification of Fruit Ripening by Suppressing Gene Expression [PDF]

Plant Physiology, 1992
Ethylene is one of the simplest organic molecules with biological activity. Its effects on plant tissue are spectacular and commercially important (1, 2). This hydrocarbon gas is generally considered to be the fruit-ripening hormone (2, 3). Because of its effects on plant senescence, large losses of fruits and vegetables are incurred annually in the ...
A, Theologis, T I, Zarembinski, P W, Oeller, X, Liang, S, Abel   +4 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Suppression of ING1 expression in sporadic breast cancer [PDF]

Oncogene, 1999
Down regulation of the ING1 candidate tumour suppressor promotes growth in soft agar and focus formation in vitro and tumour formation in vivo. ING1 encodes a nuclear, cell cycle-regulated protein, overexpression of which efficiently blocks cell growth and is capable of inducing apoptosis in different experimental systems.
T, Toyama, H, Iwase, P, Watson, H, Muzik, E, Saettler, A, Magliocco, L, DiFrancesco, P, Forsyth, I, Garkavtsev, S, Kobayashi, K, Riabowol   +10 more
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A cross-sectional study on the influence of emotion regulation strategies on the association between trait mindfulness and suicidality

BMC Psychology
Background Several risk factors for suicidality, including dysfunctional emotion regulation strategies (ERS), have been identified. With regard to the high number of suicides worldwide, suicide prevention and identifying potentially protective factors is
Inken Höller, Judith Martens, Christina Fönschau, Thomas Forkmann   +3 more
doaj   +1 more source

Behavioral Inhibition and Activation Systems, and Emotional Regulation in Individuals With Chronic Musculoskeletal Pain

Frontiers in Psychiatry, 2018
Gray's Reinforcement Sensitivity Theory postulates two distinct neurophysiological systems that underlie thoughts, emotions, and behavior: the Behavioral Inhibition System (BIS) and the Behavioral Approach System (BAS). Preliminary research suggests that
Elena R. Serrano-Ibáñez, Elena R. Serrano-Ibáñez, Carmen Ramírez-Maestre, Carmen Ramírez-Maestre, Alicia E. López-Martínez, Alicia E. López-Martínez, Rosa Esteve, Rosa Esteve, Gema T. Ruiz-Párraga, Gema T. Ruiz-Párraga, Mark P. Jensen   +10 more
doaj   +1 more source