Results 61 to 70 of about 7,978 (249)

A conditional silencing suppression system for transient expression [PDF]

Scientific Reports, 2018
AbstractRNA silencing is a powerful tool deployed by plants against viral infection and abnormal gene expression. Plant viruses have evolved a suite of silencing suppressors for counter-defense, which are also widely used to boost transcript and protein accumulation in transient assays.
Rodrigo Siqueira Reis, Celso G. Litholdo, Julia Bally, Thomas H. Roberts, Peter M. Waterhouse   +4 more
openaire   +5 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification [PDF]

Journal of Investigative Dermatology, 2006
Rab33A, a member of the small GTPase superfamily, is an X-linked gene that is expressed in brain, lymphocytes, and normal melanocytes, but is downregulated in melanoma cells. We demonstrate that in normal melanocytes Rab33A colocalizes with melanosomal proteins and that a constitutively active GTPase mutant suppresses their transport to the melanosomes.
Cheng, Elaine, Trombetta, Sergio E., Kovacs, Daniela, Beech, Robert D., Ariyan, Stephan, Reyes-Mugica, Miguel, McNiff, Jennifer M., Narayan, Deepak, Kluger, Harriet M., Picardo, Mauro, Halaban, Ruth   +10 more
openaire   +3 more sources

Emotion Regulation Strategies and Social Media Addiction: Gender-Specific Pathways Through Social Anxiety and Depression in Youth

Human Behavior and Emerging Technologies
The increasing prevalence of social media addiction (SMA) among adolescents poses significant challenges for mental health, highlighting the need for effective prevention and intervention strategies.
Lucia Monacis, Daiana Colledani, Claudia Mortali, Pasquale Anselmi, Luis J. Gomez Perez, Bruno Genetti, Daniele Fassinato, Luisa Mastrobattista, Adele Minutillo   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The effects of sexual shame, emotion regulation and gender on sexual desire

Scientific Reports, 2023
Sexual desire is of importance to sexual health, functioning, and well-being. Although an increasing number of studies address disorders related to sexual functioning, there is still a limited understanding of the underlying individual factors affecting ...
K. W. Sævik, C. Konijnenberg
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A cross-sectional study on the influence of emotion regulation strategies on the association between trait mindfulness and suicidality

BMC Psychology
Background Several risk factors for suicidality, including dysfunctional emotion regulation strategies (ERS), have been identified. With regard to the high number of suicides worldwide, suicide prevention and identifying potentially protective factors is
Inken Höller, Judith Martens, Christina Fönschau, Thomas Forkmann   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source