Results 81 to 90 of about 64,799 (296)
Fractalkine Over Expression Suppresses α-Synuclein-mediated Neurodegeneration [PDF]
Molecular Therapy, 2015 In Parkinson's disease, α-synuclein is known to activate microglia and this activation has been proposed as one of the mechanisms of neurodegeneration. There are several signals produced by neurons that have an anti-inflammatory action on microglia, including CX3CL1 (fractalkine). We have shown that a soluble form of CX3CL1 is required to reduce neuron
Nash, Kevin R +6 more
openaire +2 more sources
Emotional suppression and well-being in immigrants and majority group members in the Netherlands [PDF]
, 2014 We were interested in interethnic differences in emotional suppression. We propose a model in which suppression of specific emotional experiences (suppressive behaviours during interactions with others) mediates the relationship between emotional ...
Arbuckle +15 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Human Behavior and Emerging TechnologiesThe increasing prevalence of social media addiction (SMA) among adolescents poses significant challenges for mental health, highlighting the need for effective prevention and intervention strategies.
Lucia Monacis +8 more
doaj +1 more source
Frontiers in Psychiatry, 2018 Gray's Reinforcement Sensitivity Theory postulates two distinct neurophysiological systems that underlie thoughts, emotions, and behavior: the Behavioral Inhibition System (BIS) and the Behavioral Approach System (BAS). Preliminary research suggests that
Elena R. Serrano-Ibáñez +10 more
doaj +1 more source
An exploratory study on internet addiction, somatic symptoms and emotional and behavioral functioning in school-aged adolescents [PDF]
, 2017 Objective: In the last two decades there has been a significant transformation regarding the use of new technologies. Despite growing acknowledgement concerning the different activities and functions of digital technologies, there remains a lack of ...
Cerutti, R. +5 more
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Chitosan‑based nanoparticles with damnacanthal suppress CRM1 expression
Oncology Letters, 2018 Cancer is one of the leading causes of mortality worldwide. Phytochemicals may be promising anticancer agents given their various chemical structures and diverse biological activities. Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preventive or chemotherapeutic agent.
Chaichanasak, Nadda +8 more
openaire +3 more sources
Foxd3 suppresses interleukin‐10 expression in B cells [PDF]
Immunology, 2017 SummaryInterleukin‐10‐positive (IL‐10+) regulatory B (Breg) cells play an important role in restraining excessive inflammatory responses by secreting IL‐10. However, it is still unclear what key transcription factors determine Breg cell differentiation.
Yu Zhang +13 more
openaire +2 more sources
BMC PsychologyBackground Several risk factors for suicidality, including dysfunctional emotion regulation strategies (ERS), have been identified. With regard to the high number of suicides worldwide, suicide prevention and identifying potentially protective factors is
Inken Höller +3 more
doaj +1 more source