Results 61 to 70 of about 4,149 (173)

Integrative Genomic Profiling of Pediatric Solid Tumors Reveals Clinically Relevant Variants and Chromosomal Arm Aneuploidies Signatures

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Pediatric malignancies have emerged as the leading cause of disease‐related mortality in children, exhibiting distinct etiological and molecular characteristics compared to adult cancers. Despite advances in genomic profiling, the molecular landscape of pediatric solid tumors, particularly in Chinese populations, remains ...
Bingxiao Yan, Jinhu Wang, Jieni Xiong, Shuangai Liu, Yinbing Tang, Ziqi He, Hujin Yan, Bize Guo, Chen Chen, Yijie Zhang, Qinfang Zhu, Jiabin Cai, Min He, Xuan Wu, Junqing Mao, Lifeng Zhang, Weizhong Gu, Zhu Zhu, Zheming Li, Rui Xiao, Qiang Shu, Gang Yu, Ting Tao   +22 more
wiley   +1 more source

Multiple Osteochondromas: Clinicopathological and Genetic Spectrum and Suggestions for Clinical Management

Hereditary Cancer in Clinical Practice, 2004
Multiple Osteochondromas is an autosomal dominant disorder characterised by the presence of multiple osteochondromas and a variety of orthopaedic deformities.
Hameetman Liesbeth, Bovée Judith VMG, Taminiau Antonie HM, Kroon Herman M, Hogendoorn Pancras CW   +4 more
doaj   +1 more source

The Tap‐to‐Safety Task: A Novel fMRI Paradigm Assessing Repetitive Threat‐Neutralization

Human Brain Mapping, Volume 47, Issue 3, 15 February 2026.
In this study, we present a novel task to model repetitive threat‐neutralization behavior during neuroimaging. Results suggest that the dorsal anterior cingulate cortex (dACC), anterior insula, and dorsal striatum interact to drive neutralization behavior in the face of perceived threats.
Hannah Berg, Riley Rozniarek, Aardron Robinson, Rayus Kuplicki, Annette Rostel, Nate Mungunkhet, Ryan Smith, H. Blair Simpson, Martin P. Paulus, Robin L. Aupperle   +9 more
wiley   +1 more source

Novel mutation of EXT2 identified in a large family with multiple osteochondromas

Molecular Medicine Reports, 2016
Multiple osteochondromas (MO), also known as hereditary multiple exostoses, is an autosomal dominant bone disorder. Mutations in exostosin glycosyl transferase‑1 (EXT1) and exostosin glycosyl transferase‑2 (EXT2), including missense, nonsense, frameshift and splice‑site mutations, account for up to 80% of reported cases. The proteins EXT1 and EXT2 form
Chen, Xiao-Jun, Zhang, Hong, Tan, Zhi-Ping, Hu, Wen, Yang, Yi-Feng   +4 more
openaire   +3 more sources

Clinical and Genetic Significance of Chromosomal Microarray Screening of Asymptomatic Newborns

Journal of Clinical Laboratory Analysis, Volume 40, Issue 3, February 2026.
Among 99 asymptomatic newborns with abnormal low‐resolution chromosomal microarray (LR‐CMA) screening, 70.7% harbored microduplication/microdeletions with syndromic implications. However, only a minority exhibited developmental concerns during early follow‐up, highlighting the need for cautious interpretation.
Naye Choi, Hwa Young Kim, Jung Min Ko
wiley   +1 more source

An efficient technique for enhancing forensic capabilities of Ext2 file system

Digital Investigation, 2007
As electronic documents become more important and valuable in the modern era, attempts are invariably made to take undue-advantage by tampering with them. Tampering with the modification, access and creation date and time stamps (MAC DTS) of digital documents pose a great threat and proves to be a major handicap in digital forensic investigation ...
Mridul Sankar Barik, Gaurav Gupta, Shubhro Sinha, Alok Mishra, Chandan Mazumdar   +4 more
openaire   +1 more source

Distinct Molecular and Prognostic Profiles of Left‐ and Right‐Sided Colorectal Cancer Revealed by NGS Analysis: The Role of SMAD4 and SETD2 Mutations

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Colorectal cancer (CRC) isthe third most common cancer and the second leading cause of cancer‐relateddeath worldwide. Its genetic heterogeneity complicates treatment. This studyaimed to compare clinicopathological, molecular, and prognostic factors betweenleft‐sided (LCC) and right‐sided (RCC) CRC.
Wenlei Zhao, Yuxuan Qiu, Na Bai, Chunhong He, Jiani C. Yin, Qianru Xu, Kaiyu Jian, Baolei Jia, Lin Jiang, Feng Liang   +9 more
wiley   +1 more source

Hereditary Multiple Exostoses: Current Insights

Orthopedic Research and Reviews, 2019
Antonio D’Arienzo, Lorenzo Andreani, Federico Sacchetti, Simone Colangeli, Rodolfo Capanna Department of Translational Research on New Surgical and Medical Technologies, University of Pisa, Pisa, ItalyCorrespondence: Federico SacchettiDepartment of
D'Arienzo A, Andreani L, Sacchetti F, Colangeli S, Capanna R   +4 more
doaj  

MMP2 Sheds Glypican‐4 to Suppress Slit3‐Robo4 Signaling and Angiogenesis

Proteoglycan Research, Volume 4, Issue 1, January 2026.
ABSTRACT Axon guidance molecules, initially identified for their roles in neural development, are now recognized as crucial regulators of angiogenesis and blood vessel patterning. Among these, Slit3 promotes endothelial cell migration, proliferation, and vascular network formation by signaling through the endothelial‐specific receptor Robo4.
Wenyuan Xiao, Alexander R. Orta, Jingwen Yue, Xuehong Song, Huquan Yin, Lianchun Wang   +5 more
wiley   +1 more source

Subscapular Fossa Osteochondroma: A Case Report of an Anatomical Surgical Approach

Case Reports in Orthopedics, Volume 2026, Issue 1, 2026.
Introduction Subscapular osteochondromas are rare lesions, and reports describing their management through the medial paravertebral longitudinal approach are scarce. This case highlights the surgical management of a giant symptomatic osteochondroma with suspected malignant transformation using a muscle‐sparing approach that provided excellent ...
Carina Codau, Albert Ferrando, Shashank Kaushik   +2 more
wiley   +1 more source