Results 1 to 10 of about 1,735 (162)

Outcomes of Temporary Hemiepiphyseal Stapling for Correcting Genu Valgum in Children with Multiple Osteochondromas: A Single Institution Study [PDF]

Children, 2021
Background: Multiple osteochondromas is a rare skeletal disorder characterized by the presence of osteocartilaginous protrusions causing bony deformities, especially around the knee.
Giovanni Trisolino, Manila Boarini, Marina Mordenti, Andrea Evangelista, Giovanni Gallone, Stefano Stallone, Paola Zarantonello, Diego Antonioli, Giovanni Luigi Di Gennaro, Stefano Stilli, Luca Sangiorgi   +10 more
doaj   +4 more sources

A rare case of hereditary multiple osteochondromas [PDF]

The Pan African Medical Journal, 2020
Five (5) years old male patient came to outpatient department with complain of multiple swelling over chest region with upper extremities. The clinical examination revealed that there is chest multiple mass growth of about 3-4 cm bilaterally each over ...
Rakesh Khatana, Renu Rathi
doaj   +5 more sources

Cases report: Mosaic structural variants of the EXT1 gene in previously genetically unconfirmed multiple osteochondromas [PDF]

Frontiers in Genetics
Multiple osteochondromas (MO) is a rare autosomal dominant skeletal disorder characterized by the development of multiple benign tumors known as osteochondromas. The condition is predominantly caused by loss-of-function variants in the EXT1 or EXT2 genes,
Artem Borovikov, Andrey Marakhonov, Aysylu Murtazina, Kseniya Davydenko, Alexandra Filatova, Nailya Galeeva, Varvara Kadnikova, Natalya Ogorodova, Daria Gorodilova, Ilya Kanivets, Ilya Kanivets, Denis Pyankov, Konstantin Zherdev, Konstantin Zherdev, Aleksandr Petel’guzov, Pavel Zubkov, Alexander Polyakov, Olga Shchagina, Mikhail Skoblov   +18 more
doaj   +4 more sources

Structural Features of Heparan Sulfate from Multiple Osteochondromas and Chondrosarcomas [PDF]

Molecules, 2018
Multiple osteochondromas (MO) is a hereditary disorder associated with benign cartilaginous tumors, known to be characterized by absence or highly reduced amount of heparan sulfate (HS) in the extracellular matrix of growth plate cartilage, which alters ...
Noemi Veraldi, Alessandro Parra, Elena Urso, Cesare Cosentino, Manuela Locatelli, Serena Corsini, Elena Pedrini, Annamaria Naggi, Antonella Bisio, Luca Sangiorgi   +9 more
doaj   +4 more sources

Multiple osteochondromas [PDF]

Orphanet Journal of Rare Diseases, 2008
Multiple osteochondromas (MO) is characterised by development of two or more cartilage capped bony outgrowths (osteochondromas) of the long bones. The prevalence is estimated at 1:50,000, and it seems to be higher in males (male-to-female ratio 1.5:1 ...
Bovée Judith VMG
doaj   +4 more sources

Hereditary multiple osteochondromas

Portuguese Journal of Pediatrics
A three-year-old boy’s mother reports the appearance of painless swelling at the right tibia’s proximal end, with one year of evolution, without previous trauma or local/systemic inflammatory signs, namely fever or lymphadenopathy.
João R. Nunes-Pires, Violeta Florova, Teresa Alves-da Silva   +2 more
doaj   +4 more sources

Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb) [PDF]

Human Mutation, 2009
Multiple osteochondromas (MO) is an autosomal dominant skeletal disease characterized by the formation of multiple cartilage-capped bone tumors growing outward from the metaphyses of long tubular bones. MO is genetically heterogeneous, and is associated with mutations in Exostosin-1 (EXT1) or Exostosin-2 (EXT2), both tumor-suppressor genes of the EXT ...
Elena Pedrini, Marina Mordenti, Bert Bakker   +2 more
exaly   +4 more sources

Secondary peripheral chondrosarcoma in multiple osteochondromas: a retrospective single-institution case series [PDF]

Orphanet Journal of Rare Diseases
Background Multiple osteochondromas is genetic disorder characterized by the formation of multiple benign cartilage-capped bone tumors, named osteochondromas, during skeletal development.
Maria Gnoli, Marco Gambarotti, Alberto Righi, Eric Lodewijk Staals, Andrea Evangelista, Morena Tremosini, Evelise Brizola, Marina Mordenti, Manila Boarini, Manuela Locatelli, Elena Pedrini, Luca Sangiorgi   +11 more
doaj   +2 more sources

Osteosarcoma Arising from Iliac Bone Lesions of Hereditary Multiple Osteochondromas: A Case Report [PDF]

Case Reports in Oncology
Introduction: Osteochondromas are benign tumors that arise primarily in the metaphyseal region of long bones. The malignant transformation rate is estimated to be less than 1% and 1–3% in solitary and multiple osteochondromas, respectively ...
Tadamasa Handa, Kunihiro Asanuma, Hiroto Yuasa, Tomoki Nakamura, Tomohito Hagi, Katsunori Uchida, Akihiro Sudo   +6 more
doaj   +2 more sources

Biplanar EOS screening in children with hereditary multiple osteochondromas: a feasible screening method? [PDF]

Frontiers in Pediatrics
BackgroundChildren with Hereditary Multiple Ostechondromas (HMO) require regular screening to identify gradual dysplasia or osteochondromas that need surgery.
Henrik Hedelin, Henrik Hedelin, Jenny Ahlin, Jenny Ahlin, Aina Danielsson, Aina Danielsson, Helena Brisby, Helena Brisby, Kerstin Lagerstrand, Kerstin Lagerstrand   +9 more
doaj   +2 more sources