Results 31 to 40 of about 3,448,511 (303)

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Nature Communications, 2023
There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +13 more
doaj   +1 more source

Antibiotic Susceptibility Pattern of Gram-negative Isolates of Lower Respiratory Tract Infection

Journal of Nepal Health Research Council, 2018
Background: Lower respiratory tract infection is a common cause of morbidity and mortality worldwide. A cross-sectional study was carried out with an objective to study the antibiogram of Gram-negative isolates of patients with lower respiratory tract ...
Rakshya Nepal, Basudha Shrestha, Deepak Man Joshi, Rajesh Dhoj Joshi, Sanjit Shrestha, Anjana Singh   +5 more
doaj   +1 more source

Successful Management of Urosepsis with Ceftriaxone+Sulbactam+EDTA: A Case Report of Penem Sparing Approach [PDF]

Journal of Clinical and Diagnostic Research, 2017
Over the past decade, the Anti-Microbial Resistance (AMR) among members of Enterobacteriaceae family is on rise mainly due to rapid spread of strains producing Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo Beta-Lactamases (MBLs).
Amit Bery, Candy Sodhi, Rishu Bhanot
doaj   +1 more source

Occurrence and characteristics of extended spectrum beta-lactamases-producing Enterobacteriaceae from foods of animal origin

Brazilian Journal of Microbiology, 2016
Presence of extended spectrum beta-lactamases (ESBL) in bacteria is a growing health concern of global significance. The local, regional, national, and international epidemiological studies for extended spectrum beta-lactamases-producing ...
I. Tekiner, H. Özpınar
semanticscholar   +1 more source

Difluoromethylenation of Alkynes: Streamlined Access to Allyl Difluorides

Angewandte Chemie, EarlyView.
Stabilizing primary oxocarbenium in HF/pyridine unlocks a direct alkyne difluoromethylenation – an efficient route to synthetically‐relevant allyl difluorides in a single step. ABSTRACT A direct difluoromethylenation of alkynes has been developed using HF/pyridine as a dual acidic and fluorinating medium. The reaction proceeds via in situ generation of
Fabien Naullet, Sourav Mondal, Frédéric Guégan, Bastien Michelet, Sébastien Thibaudeau   +4 more
wiley   +2 more sources

Nitrofurantoin and Fosfomycin for Extended Spectrum Beta-lactamases Producing Escherichia coli and Klebsiella pneumoniae

Journal of Global Infectious Diseases, 2018
Urinary tract infection (UTI) is a common and painful human illness that, unfortunately not responsive to commonly used antibiotics in current practice.
N. Tulara
semanticscholar   +1 more source

Predictors of the extended-spectrum-beta lactamases producing Enterobacteriaceae neonatal sepsis at a tertiary hospital, Tanzania

International Journal of Medical Microbiology, 2018
Highlights • ESBL-PE sepsis was predicted by admission at ICU and ESBL-PE colonization.• Neonates infected with ESBL-PE had significantly high mortality.• ESBL-producing Klebsiella pneumoniae (ST45) carrying blaCTX-M-15 were predominant.• Whole genome ...
R. Marando, J. Seni, M. Mirambo, Linda Falgenhauer, N. Moremi, Martha F. Mushi, Neema M. Kayange, Festo Manyama, C. Imirzalioglu, T. Chakraborty, S. Mshana   +10 more
semanticscholar   +1 more source

Prevalence of extended-spectrum beta-lactamases, AmpC beta-lactamase, and metallo-beta-lactamase producing Pseudomonas aeruginosa and Acinetobacter baumannii in an intensive care unit in a tertiary care hospital

Journal of the Scientific Society, 2013
Background: Resistance to broad-spectrum beta-lactams, mediated by extended-spectrum beta-lactamases (ESBL), AmpC beta-lactamase, and metallo-beta-lactamase (MBL) enzymes, is an increasing problem worldwide. Aim of the study: This study was undertaken to
Varun Goel, Sumati A Hogade, S G Karadesai   +2 more
doaj   +1 more source

Prevalence of Extended-Spectrum Beta-Lactamases-Producing Microorganisms in Patients Admitted at KRRH, Southwestern Uganda

International Journal of Microbiology, 2017
The emergence of extended-spectrum beta-lactamase- (ESBL-) producing pathogenic bacteria at Kabale Regional Referral Hospital (KRRH), located in southwestern Uganda, is of great concern: a phenomenon that worries clinicians and other healthcare workers ...
B. Andrew, A. Kagirita, J. Bazira
semanticscholar   +1 more source

Epidemiologia molecolare di Klebsiella pneumoniae produttore di beta-lattamasi ad ampio spettro (ESBL) circolante in una Terapia Intensiva Neonatale [PDF]

, 2006
The molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae was investigated in the neonatal intensive care unit (NICU) of a university hospital in Italy from September 2002 to December 2004, when 233 ...
Bagattini, Maria
core   +1 more source