Results 201 to 210 of about 251,489 (270)

GABA_A binding correlates with high-frequency EEG: a possible proxy for depolarization in traumatic brain injury. [PDF]

Brain Commun
Shah SA, Alkhoury L, Martin I, Radanovic A, Scanavini G, Hojjati SH, Chiang GC, Butler TA, Kang Y, Jamison KW, Kuceyeski A, Schiff ND.   +11 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Exploring the Holdase Activity of Supramolecular Chaperones with Amyloid-Forming Peptides and Insulin. [PDF]

Biomacromolecules
Piedmont ER, Distaffen HE, Crompton LC, Krauss TD, Nilsson BL, Partridge BE.   +5 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Ambulatory Holter Findings in Patients with Palpitations and Structurally Normal Heart: A Prospective Study of the Prevalence and Patterns of Ventricular and Supraventricular Arrhythmias. [PDF]

J Clin Med
Elenizi K, Alharthi R, Alotaibi NE, Alotaibi T, Alfraikh M, Almusayfir F, Ahmad K.   +6 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Relevance of Quantitative Measures of Beta-Cell Function in Clinical Practice.

Horm Res Paediatr
Galderisi A, Dayan CM, Colhoun HM, Gregory JM.   +3 more
europepmc   +1 more source

Optimizing and Benchmarking Machine Learning and Traditional Synaptic Event Detection Pipelines in Neurophysiology Experiments. [PDF]

eNeuro
Sevigny JP, Schrank S, Donka RM, Aguilar OD, Yunus NI, Valchinova MR, Fyke Z, Zak JD, Roitman JD, Sparta DR.   +9 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Spider Web Architecture and Rainfall Damage: Observational and Manipulative Studies Along a Precipitation Gradient on the Tropical Andes. [PDF]

Ecol Evol
Lin YH, Brescovit AD, Avilés L.
europepmc   +1 more source