Results 121 to 130 of about 6,363,847 (305)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

The value of social care professionals working in extended schools

open access: yes, 2008
The value of social care professionals working in extended ...
Anne Wilkin (20863313)   +4 more
core  

Differential impact of telehealth extended-care programs for weight-loss maintenance in African American versus white adults. [PDF]

open access: yesJ Behav Med, 2022
O'Neal LJ   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Ambulatory care report guidebook for Pre-Hospital Emergency Care Council [PDF]

open access: yes, 2011
In order to provide safe reliable healthcare to the patient it is important that the information provided is accurate, valid, reliable, timely, relevant,legible and complete.Quality Health Information is the corner stone which will ensure that ...
Pre-Hospital Emergency Care Council
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Extended Care Center

open access: yes
Letter from the Board of Trustees to Richard Gosser regarding the planned Extended Care ...

core  

Effect of statewide reduction in extended care facility use after joint replacement on hospital readmission. [PDF]

open access: yesSurgery, 2021
Schuman AD   +4 more
europepmc   +1 more source

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