Results 151 to 160 of about 15,043 (195)

Causal Structure Learning Assumptions Shape Counterfactual Safety: Expert-Guided Constraints vs. Data-Driven DAGs with Probabilistic Logic Twin Networks. [PDF]

Entropy (Basel)
Avilés H, Gracia I, Kiesel R, Rodríguez V, Machucho R, Reyes A, Negrete M, Ramírez G, Luévano N, Pequeño M, Medrano J, Weitkämper F.   +11 more
europepmc   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

A causal inference framework for poststratification: a method for improving external validity in epidemiological studies. [PDF]

BMC Med Res Methodol
Oh YW, Lee D, Cho J, Kim C, Kim KN.
europepmc   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Inferring the causes of noise from binary outcomes: A normative theory of learning under uncertainty. [PDF]

Psychol Rev
Fang X, Piray P.
europepmc   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Parameter-Independent Feature Ranking with Volume-Integrated Sharma-Mittal Entropy: Kernel-Based Estimation, Theoretical Properties and Empirical Validation. [PDF]

Entropy (Basel)
Oruç Ünal N, Göztaş M, Yıldız D.
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Quantifying and Adjusting for Verification Bias in Diagnostic Test Accuracy Studies with Conditional Reference Standards

Hudak V, Welton NJ, Derezea E, Jones HE.
europepmc   +1 more source

On the Algorithm Complexity of Generating Discrete Uniform Distribution from a Biased Coin. [PDF]

Entropy (Basel)
Zhang M, Teng G, Lei X.
europepmc   +1 more source