Results 61 to 70 of about 704 (153)

Branched‐Chain Amino and Keto Acids Reduce Hepatocyte Lipid Droplet Size and Number via Distinct Proteomic Pathways

PROTEOMICS, EarlyView.
ABSTRACT Branched‐chain amino acids (BCAA) and their corresponding keto acids (BCKA) have been associated with changes in hepatic lipid metabolism and the resulting alterations in intracellular triglyceride concentrations. In this study, we utilized a previously established hepatocyte model to investigate the impact of BCAA and BCKA supplementation on ...
Jayasimha R. Daddam, Mounica Sura, Edward Kolodziej, Maria Gojcaj, Zheng Zhou   +4 more
wiley   +1 more source

Investigating GERMs: how genotype, environment, and rhizosphere microbiome interactions underlie heat response in maize and sorghum

New Phytologist, EarlyView.
Three genotypes – a heat‐resistant maize (Zea mays), a heat‐susceptible maize, and a sorghum (Sorghum bicolor) variety – were grown to the V4 stage in growth chambers under optimal conditions or subjected to heat stress. Plants were grown in soil containing a complex microbial community, or in the same soil with a depleted microbiome.
Nate Korth, Isabella Borrero, Katelyn Rumley, Alex L. Woodley, Mallory J. Choudoir, Joseph L. Gage   +5 more
wiley   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

A STUDY OF EXTENDED BETA, GAUSS AND CONFLUENT HYPERGEOMETRIC FUNCTIONS [PDF]

International Journal of Apllied Mathematics, 2020
M. Ghayasuddin, N. Khan, M. Ali
openaire   +1 more source

An extension of Pochhammer’s symbol and its application to hypergeometric functions

, 2017
By using a special property of the gamma function, we first define a productive form of gamma and beta functions and study some of their general properties in order to define a new extension of the Pochhammer symbol.
Mohammad Masjed-Jamei, Gradimir Milovanovic   +1 more
core   +1 more source

2‐Hydroxyisobutyrylation and Phosphorylation Crosstalk Guides Metastasis Prediction and Immunotherapy in Esophageal Squamous Cell Carcinoma

MedComm, Volume 7, Issue 7, July 2026.
This study deciphers the functional crosstalk between 2‐hydroxyisobutyrylation (Khib) and phosphorylation in driving esophageal squamous cell carcinoma (ESCC) metastasis. Through multi‐omics and machine learning, we developed a plasma protein signature for noninvasive detection of lymph node metastasis.
Junyi Li, Shujun Li, Xiaomei Yu, Qier Mu, Maowen Luo, Yuzhen Wang, Zhichao Liu, Chengwei Gu, Jiaxi Chen, Wangcheng He, Tong Yang, Yan He, Xiaoya Pei, Mao Lin, Zhigang Li, Jun Liu, Baosheng Zhao, Fan Zhang, Jinbao Liu, Bin Li, Wenwen Xu   +20 more
wiley   +1 more source

Drugst.One DREAM—Drug repurposing through expert annotation and modification

British Journal of Pharmacology, Volume 183, Issue 13, Page 3503-3516, July 2026.
Background and Purpose Complex diseases often lack an actionable understanding of their underlying causal biological mechanisms, which leads to treating symptoms rather than causes. Network and systems medicine define disease mechanisms through disease‐associated genes, their encoded proteins and their protein–protein interactions (PPIs), thus forming ...
Lisa M. Spindler, Johannes Kersting, Quirin Manz, Michael Hartung, Andreas Maier, Zeinab M. Mamdouh, Ana I. Casas, Jan Baumbach, Markus List   +8 more
wiley   +1 more source

Extension of Connecting Formulas on Hypergeometric Function

The Hypergeometric series is the extension of the geometric series and the Confluent Hypergeometric Function is the solution of the Hypergeometric Differential Equation.
Bhadra Raj Tripathi
core   +1 more source

DNA Hypomethylation Is One of the Epigenetic Mechanisms Involved in Salt‐Stress Priming in Soybean Seedlings

Plant, Cell &Environment, Volume 49, Issue 7, Page 3764-3776, July 2026.
ABSTRACT Salt‐stress priming enhances the tolerance of plants against subsequent exposure to a similar stress. Priming‐induced transcriptomic reprogramming is mediated by multiple epigenetic mechanisms, the best known of which is histone modifications. However, not much is known about other epigenetic responses.
Wai‐Shing Yung, Qianwen Wang, Long‐Yiu Chan, Zhili Wang, Mingkun Huang, Man‐Wah Li, Fuk‐Ling Wong, Hon‐Ming Lam   +7 more
wiley   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source