Results 71 to 80 of about 704 (153)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, Volume 13, Issue 35, 24 June 2026.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

On some differential transformations of hypergeometric equations

, 2015
Many algebraic transformations of the hypergeometric equation σ(x)z"(x) + τ(x)z'(x) + lz(x) = 0, where σ, τ, l are polynomial functions of degrees 2 (at most), 1, 0, respectively, are well known.
Ronveaux, A., Hounkonnou, M N, 30th International Colloquium on Group Theoretical Methods in Physics (Group30), ICGTMP 2014   +2 more
core   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Endogenously generated Dutch‐type Aβ non‐fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract BACKGROUND APPE693Q (“Dutch”) transgenic mice develop aging‐related learning deficits and accumulate endogenously generated non‐fibrillar aggregates (NFAs) of amyloid beta (Aβ) and amyloid precursor protein α‐carboxy terminal fragments. NFA‐Aβ correlates with synaptic loss and memory deficits more closely than does fibrillar Aβ.
Emilie L. Castranio, Merina Varghese, Elentina K. Argyrousi, Kuldeep Tripathi, Yong Huang, Akiko Asada, Linda Söderberg, Erin Bresnahan, David Lerner, Francesca Garretti, Hong Zhang, Jonathan van de Loo, Cheryl D. Stimpson, Ronan Talty, Charles Glabe, Efrat Levy, Minghui Wang, Marjan Ilkov, Toshiharu Suzuki, Kanae Ando, Bin Zhang, Lars Lannfelt, Brigitte Guérin, William D. Lubell, Shai Rahimipour, Dara L. Dickstein, Sam Gandy, Ottavio Arancio, Michelle E. Ehrlich   +28 more
wiley   +1 more source

Electroacupuncture Ameliorates Cognitive Impairment in Vascular Dementia Rats: Potential Involvement of the Astrocyte–Synapse Axis

Brain and Behavior, Volume 16, Issue 6, June 2026.
Electroacupuncture significantly ameliorates cognitive impairment and synaptic damage in vascular dementia rats, showing specific advantages over nimodipine. These neuroprotective effects are closely associated with modulating the astrocyte–synapse axis to suppress neuroinflammation and enhance neurotrophic support.
Sijing Guo, Qian Liu, Shihao Lin, Taotao Zhou, Qin Hu, Zhongsheng Tang   +5 more
wiley   +1 more source

Artificial Sweeteners and Autoimmune Diseases: Insights From Integrative Bioinformatics and Mendelian Randomization

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study provides a novel molecular perspective on the role of AS in ADs development. We identified a positive association between artificially sweetened cereal intake and ADs risk and revealed multiple pathogenic mechanisms involving apoptosis, inflammatory signaling, immune activation, and gut microbiota dysbiosis.
Yupei Liu, Jizhen Huang, Xue Hu, Shan Tian, Jiao Li, Shiyun Tan, Weiguo Dong   +6 more
wiley   +1 more source

Multi‐Omic Profiling of Gut Microbiota and Fecal Metabolites in Patients With Polycystic Ovary Syndrome: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aim Intestinal flora composition in polycystic ovary syndrome (PCOS) varies, and the relationship between intestinal flora, fecal metabolites, clinical characteristics, and PCOS pathogenesis remains unclear. This study aimed to elucidate the gut microbiota characteristics of patients with PCOS, focusing on changes in normal ...
Yu‐Mei Li, Fang‐Fang He, Donge‐Liu, Bin‐Xu, Shuyi‐Li   +4 more
wiley   +1 more source

Integrin α5β1‐mediated multicellular crosstalk in the tumor microenvironment drives bladder cancer progression and reveals targetable vulnerabilities

iMetaOmics, Volume 3, Issue 2, June 2026.
Integrating multiplexed immunofluorescence, animal models, and clinical samples, our single‐cell and spatial atlas maps tumor microenvironment evolution during bladder cancer (BCa) progression. We reveal that stemness‐associated tumor cells (SDC1+), POSTN+ myofibroblastic cancer‐associated fibroblasts (mCAFs), and immunosuppressive monocytic myeloid ...
Ting Liang, Wuwu Xu, Hu Fang, Lu Fu, Dashi Deng, Chenchen Li, Lisha Liu, Dongdong Tang, Huancheng Yang, Fang Liu, Xing Xiong, Guangzhi Li, Song Wu, Tao Tao   +13 more
wiley   +1 more source

Genetic dissection of plant architecture, development, and seed morphology in exotic × elite Upland cotton populations

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Cotton (Gossypium hirsutum L.) breeding has primarily emphasized fiber yield and quality, yet plant architectural, developmental, and seed morphological traits also play key roles in productivity and management. Here, we dissect the genetic basis of four such traits: plant height (HT), number of nodes with one branch (N1B), days to flowering ...
Hrithik Mangla, Ankush Sharma, Min Liu, Tariq Shehzad, Gary J. Pierce, Rahul Chandnani, Sayan Das, Sameer Khanal, Jason G. Wallace, John L. Snider, Don C. Jones, Peng W. Chee, Andrew H. Paterson   +12 more
wiley   +1 more source

Supersymmetry in the Quark-Diquark and the Baryon-Meson Systems

, 2011
A superalgebra extracted from the Jordan algebra of the 27 and 27 dim. representations of the group E6 is shown to be relevant to the description of the quark-antidiquark system. A bilocal baryon-meson field is constructed from two quark-antiquark fields.
Catto, S., Choun, Y.
core   +1 more source