Results 71 to 80 of about 8,499 (170)

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, EarlyView.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

Solutions for the General, Confluent and Biconfluent Heun equations and their connection with Abel equations

, 2004
In a recent paper, the canonical forms of a new multi-parameter class of Abel differential equations, so-called AIR, all of whose members can be mapped into Riccati equations, were shown to be related to the differential equations for the hypergeometric ...
Abramowitz M, Anguelova L, Chan L Cheb-Terrab E S, Cheb-Terrab E S, Decarreau A, E S Cheb-Terrab, Erdélyi A, Exton H, Finkel F, Gagnon L, Ishkhanyan1 A, Ishkhanyan1 A, Kamke E, Kovacic J, Maier R S, Polyanin A D, Ronveaux A, Ronveaux A, Sachdev P L, Slavyanov S Y, Smirnov A O, Stephani H, Whittaker E T   +22 more
core   +4 more sources

Flow of Elastoviscous Nanofluid Through an Elongating Surface With Dissipative Heat: A Confluent Hypergeometric Solution

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Thermal energy transport likely through polymer extrusion, cooling of metallic plates, and chemical processing equipment relating to the flow of viscoelastic nanofluid has a greater role in engineering because of its elastic characteristics.
Rupa Baithalu, S. R. Mishra, Ram Prakash Sharma, Laxmipriya Swain   +3 more
wiley   +1 more source

Alternative Price Dynamics and Valuation of Flexible Strategies

International Journal of Finance &Economics, EarlyView.
ABSTRACT In this article, we study the optimal operational strategy of production projects. We investigate different underlying price models and determine the optimal barriers of transition to suspension, recovery, or irreversible abandonment of productive activity.
Cristina Bertolosi, Gianluca Fusai, Ioannis Kyriakou   +2 more
wiley   +1 more source

A new Generalization of Extended Beta and Hypergeometric Functions

, 2018
A new generalization of extended beta function and its various properties, integral representations and distribution are given in this paper. In addition, we establish the generalization of extended hypergeometric and confluent hypergeometric functions ...
K. Nisar, G. Rahman, S. Mubeen
semanticscholar   +1 more source

Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes

Andrology, EarlyView.
ABSTRACT Background Epidemiological studies have reported an association between advanced paternal age at conception and an increased risk of neurodevelopmental disorders in offspring, such as autism spectrum disorder. Evidence suggests that DNA methylation alterations in spermatozoa of older men may be transmitted to the feto‐placental unit and ...
Julia Barnwell, Sophia Rahimi, Sherri Lee Jones, Donovan Chan, Josée Martel, Sara Abdessamie, Catherine M. Herba, Jean R. Séguin, William D. Fraser, Celia M. T. Greenwood, Tuong‐Vi Nguyen, Tina C. Montreuil, Jacquetta Trasler   +12 more
wiley   +1 more source

Fractional integral operator associated with extended Mittag-Leffler function

International Journal of Advances in Applied Sciences, 2019
Popular literature of Special Functions includes the generalization and extensions of functions like gamma function, beta function, Mittag-Leffler function, hypergeometric function and confluent hypergeometric function etc.
A. Nadir, Lahore Pakistan Economics, Adnan Khan   +2 more
semanticscholar   +1 more source

Do temporary changes in earnings caused by mean reversion affect firms’ refinancing decisions?

Journal of Financial Research, EarlyView.
Abstract We develop a dynamic two‐stage trade‐off model with refinancing when earnings are mean reverting. Our model predicts a negative relation between profitability and leverage at refinancing due to conservative debt increases. With multiple rounds of refinancing, the leverage–profitability relation may turn positive when firms have substantial ...
Elettra Agliardi, Marios Charalambides, Md Shahedur R. Chowdhury, Nicos Koussis   +3 more
wiley   +1 more source