Results 71 to 80 of about 8,523 (167)

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Solutions to position-dependent mass quantum mechanics for a new class of hyperbolic potentials

, 2013
We analytically solve the position-dependent mass (PDM) 1D Schr\"odinger equation for a new class of hyperbolic potentials $V_q^p(x) = -V_0\frac{\sinh^px}{\cosh^qx}, \, p= -2, 0, \dots q$ [see C. A. Downing, J. Math. Phys.
Christiansen, H. R., Cunha, M. S.
core   +1 more source

Third-order strong differential subordinations involving fractional integral of confluent (Kummer) and Gaussian hypergeometric functions

General mathematics
For the study presented in this paper, the concepts specific to strong differential subordination theory, introduced for the second-order differential subordination case, are extended for the third-order differential subordination case.
Lavinia Florina Preluca
semanticscholar   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Ince's limits for confluent and double-confluent Heun equations

, 2005
We find pairs of solutions to a differential equation which is obtained as a special limit of a generalized spheroidal wave equation (this is also known as confluent Heun equation).
Abramowitz M., Arscott F. M., B. D. Bonorino Figueiredo, Bühring W., Decarreau A., Decarreau A., Erdélyi A., Ince E. L., Lemieux A., Luke Y. L., McLachlan E. W., Olver F. M.J., Poole E. G.C., Poole E. G.C., Ronveaux A., Schmidt D.   +15 more
core   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

Solutions for the General, Confluent and Biconfluent Heun equations and their connection with Abel equations

, 2004
In a recent paper, the canonical forms of a new multi-parameter class of Abel differential equations, so-called AIR, all of whose members can be mapped into Riccati equations, were shown to be related to the differential equations for the hypergeometric ...
Abramowitz M, Anguelova L, Chan L Cheb-Terrab E S, Cheb-Terrab E S, Decarreau A, E S Cheb-Terrab, Erdélyi A, Exton H, Finkel F, Gagnon L, Ishkhanyan1 A, Ishkhanyan1 A, Kamke E, Kovacic J, Maier R S, Polyanin A D, Ronveaux A, Ronveaux A, Sachdev P L, Slavyanov S Y, Smirnov A O, Stephani H, Whittaker E T   +22 more
core   +4 more sources

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source