Results 41 to 50 of about 214,201 (239)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Fast Extended Depth-of-Field Reconstruction for Complex Holograms Using Block Partitioned Entropy Minimization

Applied Sciences, 2018
Optical scanning holography (OSH) is a powerful and effective method for capturing the complex hologram of a three-dimensional (3-D) scene. Such captured complex hologram is called optical scanned hologram. However, reconstructing a focused image from an
Peter Wai Ming Tsang, Ting-Chung Poon, Jung-Ping Liu   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Distribution of the complex amplitude and intensity in a 3D scattering pattern formed by the optical system for an on-axis point object [PDF]

Компьютерная оптика, 2018
A quantitative evaluation of the depth of field of optical systems is given. Results of the calculation of the distribution of the complex amplitude and intensity in a three-dimensional scattering pattern formed by the optical system for an on-axis point
Sergey Koreshev, Denis Smorodinov, Oleg Nikanorov, Marina Alexeevna Frolova   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Penetration of non-uniform electromagnetic field into conducting body

Electrical engineering & Electromechanics, 2021
The study is based on the exact analytical solution for the general conjugation problem of three-dimensional quasi-stationary field at a flat interface between dielectric and conducting media.
Yu. M. Vasetsky
doaj   +1 more source

Extending the depth-of-field of imaging systems with a scattering diffuser [PDF]

Scientific Reports, 2019
AbstractLarge depth of field (DOF) is a longstanding goal in optical imaging field. In this paper we presented a simple but efficient method to extend the DOF of a diffraction-limited imaging system using a thin scattering diffuser. The DOF characteristic of the imaging system with random phase modulation was analyzed based on the analytical model of ...
Meihua Liao, Dajiang Lu, Giancarlo Pedrini, Wolfgang Osten, Guohai Situ, Wenqi He, Xiang Peng   +6 more
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source