Results 121 to 130 of about 645,192 (310)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Energy Systems Integration Facility (ESIF) Fact Sheets
, 2011 This fact sheet describes the purpose, lab specifications, applications scenarios, and information on how to partner with NREL's Manufacturing Laboratory at the Energy Systems Integration Facility.
core +1 more source
, 2020 Systematically evaluating the emission intensity and total emission of industries is indispensable for understanding energy and environmental sector performance in general and to support scientific climate change policy-making.
Huang, Gordon +5 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Harnessing machine learning algorithms to unveil energy efficiency investment archetypes
Publisher Copyright: © 2024 The Author(s)Increasing transparency about the performance of different projects is crucial to reducing the heterogeneity in the energy efficiency services market, thereby upscaling investments.
Keppo, Ilkka, Koutsandreas, Diamantis
core +1 more source
New bounds of extended energy of a graph
, 2022 Extended adjacency matrix of a graph with $n$ vertices is a real symmetric marix of order $n\times n$ whose $(i,j)$-th entry is the average of the ratio of the degree of the vertex $i$ to that of the vertex $j$ and its reciprocal when $i,j$ are adjacent,
Nayeem, Sk. Md. Abu, Mandal, Abujafar
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
International Journal of Electrical Power & Energy SystemsThe operation of hydrokinetic turbines under blockage conditions causes situations where the classical power coefficient does not adequately explain their energy extraction, often exceeding Betz’s limit, as it is referred only to the kinetic energy of ...
Manuel Rico-Secades +5 more
doaj +1 more source
, 2022 S.809This paper summarizes some major recent empirical studies on export market penetration and policy issues regarding renewable energy technologies (RETS ) undertaken in Germany and Switzerland, that are yet unpublished in the English literature ...
Mannsbart, W., Madlener, R., Jochem, E.
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