Results 131 to 140 of about 645,192 (310)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

On the Extended Adjacency Eigenvalues of Graphs and Applications

Mathematics
Let Aex(G) be the extended adjacency matrix of G. The eigenvalues of Aex(G) are called extended adjacency eigenvalues of G. The sum of the absolute values of eigenvalues of the Aex-matrix is called the extended adjacency energy Eex(G) of G. In this paper,
Hilal A. Ganie, Amal Alsaluli
doaj   +1 more source

Extended CO Solid: A New Class of High Energy Density Material [PDF]

, 2004
Covalently bonded extended phases of molecular solids made of first- and second-row elements at high pressures are a new class of materials with advanced optical, mechanical and energetic properties.
Lipp, M. J., Baer, B. J., Yoo, C., Evans, W. J.   +3 more
core  

Carbon Emissions Pinch Analysis (CEPA) for emissions reduction in the New Zealand electricity sector

, 2010
Carbon Emissions Pinch Analysis (CEPA) is a recent extension of traditional thermal and mass pinch analysis to the area of emissions targeting and planning on a macro-scale (i.e. economy wide).
Walmsley, Michael R.W., Morrison, Andrew S., Atkins, Martin John   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Designing low carbon buildings : a framework to reduce energy consumption and embed the use of renewables

, 2013
EU policies to mitigate climate change set ambitious goals for energy and carbon reduction for the built environment. In order meet and even exceed the EU targets the UK Government's Climate Change Act 2008 sets a target to reduce greenhouse gas ...
Lord, Richard; id_orcid, Dawood, N., Lord, Richard, Crosbie, Tracey; id_orcid, Dawood, Saad, Dawood, Nashwan, Crosbie, Tracey   +6 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Welcome to the Second Volume of Trends in Renewable Energy

, 2016
With the help of all authors and enthusiastic editorial team members, the Trends in Renewable Energy (TRE) completed the publication of first volume. We deeply appreciate your support, and are looking forward to continuously working with all colleagues ...
Zhang, Bo
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source