Results 191 to 200 of about 40,608 (254)
Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model
British Journal of Pharmacology, Volume 183, Issue 10, Page 2236-2255, May 2026.Abstract Background and Purpose
Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray +19 morewiley +1 more sourceSingle-cell and isoform-specific translational profiling of the mouse brain. [PDF]
NatureSison SL, Zampa F, Kofman ER, Choi SY, Jagannatha P, Nguyen GG, Naritomi JT, Shin A, Khorgade A, Jin W, Chen CY, Sievert DM, Mukhopadhyay S, Mizrahi O, Blue SM, Marina RJ, Yang D, Wang CC, Pang Z, Brannan KW, Ye L, Al'Khafaji AM, Yeo GW, Lippi G. +23 moreeuropepmc +1 more sourceBeyond Co‐Occurrence: Multi‐Scale Evidence for Segregation‐Dominated Plant Networks in the French Alps
Ecology Letters, Volume 29, Issue 5, May 2026.Using high‐resolution spatial data and a multi‐scale statistical framework, we disentangle plant co‐occurrence from true spatial associations across alpine communities in the French Alps. We discovered that local species associations are dependent on soil acidity and nitrogen rather than temperature. By building a global network from these associations,Matthias Rohr, Alexandre Wendling, Tamara Münkemüller, Dominique Gravel, Clovis Galiez, Julien Renaud, Orchamp Consortium, Wilfried Thuiller +7 morewiley +1 more sourceArabidopsis acclimation to daily environmental fluctuations converts a defense response regulator into a susceptibility factor toward Sclerotinia
New Phytologist, Volume 250, Issue 4, Page 2516-2534, May 2026.Summary Acclimation enables plants to adjust to immediate environmental fluctuations and is therefore key to the resilience of plant disease resistance in a time of climate change. Here, we report on the acclimation of Arabidopsis thaliana quantitative immune responses against the fungal pathogen Sclerotinia sclerotiorum to daily environmental ...Marie Didelon, Justine Sucher, Florent Delplace, Pedro Carvalho‐Silva, Matilda Zaffuto, Adelin Barbacci, Sylvain Raffaele +6 morewiley +1 more sourceAndrogen activity in the male embryonic hindbrain drives lethal PFA ependymoma. [PDF]
NatureZhang J, Ong W, Rasnitsyn A, Gonzalez RD, Lopez Gutierrez R, Balin P, Saadeldin A, Wu X, Vladoiu MC, Santa-Maria Lopez V, Gonzalez-Salinas F, Yadav N, Mohanakrishnan D, Boosi Narayana Rao K, Mooli RGR, Najem H, Pacheco S, Kharas K, Richman C, Przelicki D, Wang EY, Su H, Curry RN, Yang R, Kameda-Smith MM, Livingston B, Scott D, Luo Z, Xia M, Abeysundara N, Erickson AW, Mankahla N, Hu LZ, Pan C, Suarez R, Huang N, Wu Y, Wang H, Douglas T, Pallota J, Hébert S, Ng K, Mantione K, Whetstone H, Maan H, Lakkis H, Lee J, Ramakrishnan SK, Pei Y, Tang Y, Lin FY, Aldave G, Gallo M, Friedlander RM, Notta F, Donovan LK, Chintagumpala M, Wang B, Li Y, De Carvalho DD, Zhang Z, Mao Y, Hua W, Eberhart C, Lucas CG, Venneti S, Sorensen PH, Delaidelli A, Li H, Zhou W, Kirk J, Tang DG, Jiang T, Liu H, Lathia JD, Suzuki H, Rich JN, Stein LD, Jabado N, Ramaswamy V, Lu QR, Heimberger AB, Daniels C, Michealraj KA, Kleinman CL, Taylor MD. +85 moreeuropepmc +1 more sourceMass Spectrometry Imaging Combined With Single‐Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata
Plant Biotechnology Journal, Volume 24, Issue 5, Page 2876-2890, May 2026.ABSTRACT
The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐HaiSheng Zeng, MeiHui Shi, ZhiRong Chen, XueJing Sun, HuiJie Zhang, Yue Huang, YuCheng Chen, Jun Ren, HuiLing Huang, Almaz Borjigidai, Man Zhang, SuJuan Duan, Yi‐Jun Chen, Hong‐Lei Jin, Hong‐Bin Wang +14 morewiley +1 more sourceMultidimensional profiling of heterogeneity in supratentorial ependymomas. [PDF]
NatureJeong D, Danielli SG, Maaß KK, Ghasemi DR, Tetzlaff SK, Reyhan E, Jiang L, Katiyar S, Sundheimer JK, Lo Cascio C, Neyazi S, de Biagi-Junior CAO, Couvillon E, Castellani S, Pazyra-Murphy M, Mullally M, Dehler MP, Englinger B, Nascimento A, Cruzeiro GAV, Marques JG, Haase RD, Nguyen CM, Baumgartner AC, Rozowsky JS, Hack OA, Shaw ML, Lotsch-Gojo D, Bruckner K, Korshunov A, Pfister SM, Kool M, Nowakowski TJ, Gojo J, Baird L, Alexandrescu S, Pajtler KW, Venkataramani V, Filbin MG. +38 moreeuropepmc +1 more sourceTranscription Profiling of Potato Leaves in Response to Heat Stress at Single‐Cell Resolution
Plant Biotechnology Journal, Volume 24, Issue 5, Page 2970-2987, May 2026.ABSTRACT
Potato (Solanum tuberosum L.) is a globally important food crop with considerable nutritional and economic value. Heat stress significantly inhibits potato plant growth and tuber development, constraining the sustainable development of the potato industry. Currently, studies on the cellular‐level mechanisms underlying heat adaptation in potato Shiqi Wen, Ke Wang, Wenqian Liang, Rongrong Liu, Zihan Li, Xinlong Chen, Yan Li, Dianqiu Lv, Hongju Jian +8 morewiley +1 more source
