Results 201 to 210 of about 40,502 (261)

Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes. [PDF]

Nat Commun
Uusküla-Reimand L, Lee CA, Oh RH, Klein ZP, Adler N, Akhtar Alvi S, Langille E, Pasini E, Cheng KCL, Serafimova E, Abd-Rabbo D, Hou H, Tsai R, Bhat M, Schramek D, Wilson MD, Reimand J.   +16 more
europepmc   +1 more source

Identification of Glioma Phenotypic Subtypes From Multimodal MRI Data Using Hierarchical Multi‐Kernel Learning

Cancer Medicine, Volume 15, Issue 2, February 2026.
Our study identified glioma phenotypic subtypes based on T1CE and T2FLAIR radiomic features, along with associated pathway activities, providing real‐time insights into tumor dynamics to guide preoperative clinical decision‐making and improve patient management.
Junyu Yan, Min Hao, Tong Wang, Qi Yang, Congcong Jia, Wenju Niu, Yan Tan, Hui Zhang, Hongyan Cao, Guoqiang Yang   +9 more
wiley   +1 more source

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks. [PDF]

Nat Genet
Ho CH, Dippel MA, McQuade MS, Nguyen LP, Mishra A, Pribitzer S, Hardy S, Chandok H, Chardon FM, McDiarmid TA, DeBerg HA, Buckner JH, Shendure J, de Boer CG, Guo MH, Tewhey R, Ray JP.   +16 more
europepmc   +1 more source

Single‐cell analysis reveals cytotoxic and memory CD8+ T cells associated with prolonged survival in relapsed/refractory leukaemia patients after haplo+cord haematopoietic stem cell transplantation

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. Haplo+cord HSCT yields superior survival compared with single cord HSCT in patients with R/R leukaemia. 2. Single‐cell RNA‐seq revealed a functionally critical CD8⁺ T cell population, with cytotoxic and memory phenotypes, which expands after haplo+cord HSCT and tracks with prolonged survival. 3. Multi‐omics profiling at single‐cell resolution showed
Hua Li, Zheyang Zhang, Ming Zhu, Xiaofan Li, Jinxian Dai, Ping Chen, Fei Chen, Xianling Chen, Yiding Yang, Xiaohong Yuan, Ronghan Tang, Zhijuan Zhu, Hongli Lin, Ting Lin, Mengsha Tong, Tao Chen, Yuanzhong Chen, Jialiang Huang, Nainong Li   +18 more
wiley   +1 more source

Region-specific gene expression and sex inform about disease susceptibility in the aorta. [PDF]

Nat Cardiovasc Res
Romay MC, Ma F, Mompeón A, Silvestro M, Hernandez GE, Salvador J, Wang AL, Vandestienne M, Bardin N, Blot-Chabaud M, Leroyer AS, Ait-Oufella H, Ramkhelawon B, Iruela-Arispe ML.   +13 more
europepmc   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

Co-Conservation of synaptic gene expression and circuitry in collicular neurons. [PDF]

Nat Commun
Liu Y, McDaniel JA, Chen C, Yang L, Kipcak A, Savier EL, Erisir A, Cang J, Campbell JN.   +8 more
europepmc   +1 more source

Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment

Human Brain Mapping, Volume 47, Issue 2, February 1, 2026.
Morphological alterations related to depressive symptoms in mild cognitive impairment were primarily involved in emotion and affective processing, showing strong correspondence with serotonergic, dopaminergic, and GABAergic systems and enrichment of genes associated with synaptic function and excitatory neurons.
Hu Xu, Yang Li, Chensi Li, Fenglin Xu, Yun Liu, Kehan Yan, Shiyi Chen, Wenxiu Song, Yifeng Luo, Yuefeng Li   +9 more
wiley   +1 more source

Cambium LBDs promote radial growth by regulating PLL-mediated pectin metabolism. [PDF]

Nat Plants
Ye L, Wang X, Valle-Delgado JJ, Vainonen JP, Wopereis I, Kesari KK, Takahashi J, Sierla M, Mähönen AP.   +8 more
europepmc   +1 more source

High‐ and Low‐Protein Maternal Diet During Pregnancy Alter the Offspring Skeletal Muscle Transcriptome and miRNAome in Lamb

New Zealand Journal of Agricultural Research, Volume 69, Issue 1, February 2026.
Maternal nutrition during gestation is a crucial factor affecting offspring development. This study explores the impact of maternal dietary protein levels on the transcriptome and miRNAome of skeletal muscle in lambs. Twelve Akkaraman breed ewes were assigned to three dietary groups—standard (SP, 119–198 g/day), high (HP, 160–270 g/day), and low (LP ...
Bilal Akyüz, Md Mahmodul Hasan Sohel, Yusuf Konca, Korhan Arslan, Kutlay Gürbulak, Murat Abay, Mahmut Kaliber, Stephen N. White, Mehmet Ulas Cinar   +8 more
wiley   +1 more source