Results 61 to 70 of about 40,608 (254)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Journal of Mathematics, 2021 In this paper, a new confluent hypergeometric gamma function and an associated confluent hypergeometric Pochhammer symbol are introduced. We discuss some properties, for instance, their different integral representations, derivative formulas, and ...
Abdus Saboor +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Mathematics, 2015 In a joint paper with Srivastava and Chopra, we introduced far-reaching generalizations of the extended Gammafunction, extended Beta function and the extended Gauss hypergeometric function.
Rakesh K. Parmar
doaj +1 more source
The Extended Laguerre Polynomials Aq,nαx Involving Fqq,q>2
Journal of Function Spaces, 2022 In this paper, for the proposed extended Laguerre polynomials Aαq,nx, the generalized hypergeometric function of the type Fqq,q>2 and extension of the Laguerre polynomial are introduced.
Adnan Khan +3 more
doaj +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
An Extended k-type Hypergeometric Functions
, 2017 Hypergeometric functions and their generalizations play an important r les in diverse applications. Many authors have been established generalizations of hypergeometric functions by a number ways. In this paper, we aim at establishing (presumably new) extended $k-$type hypergeometric function $_{2}f_{1}^{k}[a, b; c; ; z]$ and study various ...
Agarwal, Praveen, Jleli, Mohamed
openaire +2 more sources
Investigation of Extended k-Hypergeometric Functions and Associated Fractional Integrals
Mathematical Problems in Engineering, 2021 Hypergeometric functions have many applications in various areas of mathematical analysis, probability theory, physics, and engineering. Very recently, Hidan et al. (Math. Probl. Eng., ID 5535962, 2021) introduced the (p, k)-extended hypergeometric functions and their various applications.
Mohamed Abdalla +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He +10 more
wiley +1 more source
Journal of Mathematics, 2021 In this paper, the generalized fractional integral operators involving Appell’s function F3⋅ in the kernel due to Marichev–Saigo–Maeda are applied to the p,q-extended Struve function.
Haile Habenom, Abdi Oli, D. L. Suthar
doaj +1 more source