Results 151 to 160 of about 6,537,748 (290)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Reply to the Correspondence on "Can Charge Transfer Across C-H···O Hydrogen Bonds Stabilize Oil Droplets in Water?" [PDF]

Angew Chem Int Ed Engl
Zhao R, Shen H, LaCour RA, Heindel JP, Head-Gordon M, Head-Gordon T.   +5 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Phase sensitive amplification in a highly nonlinear lead-silicate fibre

We experimentally demonstrate phase-sensitive amplification in a highly nonlinear lead-silicate W-type fibre. A phase-sensitive gain swing of 6dB was observed in a 1.56m sample of the fibre for a total launched power of ...
Shi, J.D., Petropoulos, P., Richardson, D.J., Poletti, F., Kakande, J., Loh, W.H., Ettabib, M.A., Petrovich, M.N., Ponzo, G.M., Jones, L., Slavík, R., Parmigiani, F., Feng, X.   +12 more
core   +1 more source

Imaging of nanoscale polar textures in quantum paraelectric SrTiO₃. [PDF]

Nature
Zhang Y, Sung SH, Agarwal N, Gates M, Li C, Yu P, Hovden R, El Baggari I.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Decoupling the effects of surface morphology and interfacial chemistry on localized electrochemical kinetics in LiCoO₂ cathodes. [PDF]

Chem Sci
Guan Y, Wang P, Gao N, Liu P, Cao W, Ding S, Meng L, Xi K, Gao R.   +8 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Effects of Switching Angle Phase Shift on PWM Techniques

, 1987
Wiechmann, E, Manias, S, Ziogas, P
core   +1 more source

Changes in interlimb coordination induced by within-stride changes in treadmill speed. [PDF]

J Neurophysiol
Hall BL, Roemmich RT, Banks CL.
europepmc   +1 more source