Results 51 to 60 of about 94,318 (256)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Research on the Cooperative Target State Estimation and Tracking Optimization Method of Multi-UUV

Sensors, 2023
This work studied two sub-problems of the cooperative state estimation and cooperative optimization of tracking paths in multiple unmanned underwater vehicle (multi-UUV) cooperative target tracking.
Tao Chen, Qi Qi
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Box-Particle Labeled Multi-Bernoulli Filter for Multiple Extended Target Tracking [PDF]

Radioengineering, 2016
This paper focuses on real-time tracking of multiple extended targets in clutter based on labeled multi-Bernoulli filter. To address this problem, a novel approach is proposed within the recently presented box-particle framework.
M. Li, Z. Lin, W. An, Y. Zhou
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Manoeuvre Target Tracking in Wireless Sensor Networks Using Convolutional Bi-Directional Long Short-Term Memory Neural Networks and Extended Kalman Filtering

Sensors
Aiming at the problem that traditional wireless sensor networks produce errors in the positioning and tracking of motorised targets due to noise interference, this paper proposes a motorised target tracking method with a convolutional bi-directional long
Duo Peng, Kun Xie, Mingshuo Liu
doaj   +1 more source

Extended Target Shape Estimation by Fitting B-Spline Curve

Journal of Applied Mathematics, 2014
Taking into account the difficulty of shape estimation for the extended targets, a novel algorithm is proposed by fitting the B-spline curve. For the single extended target tracking, the multiple frame statistic technique is introduced to construct the ...
Jin-long Yang, Peng Li, Hong-wei Ge
doaj   +1 more source

Tracking Algorithms Aided by the Pose of Target

IEEE Access, 2019
The traditional target tracking algorithms have utilized the information on the target position. With the development of radar high-resolution technology, it is possible to obtain the pose of target. In this paper, two target tracking algorithms aided by
Dai Liu, Yongbo Zhao, Baoqing Xu
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Passive Sonar Multiple-Target Tracking with Nonlinear Doppler and Bearing Measurements Using Multiple Sensors

International Journal of Aerospace Engineering, 2021
The major advantage of the passive multiple-target tracking is that the sonars do not emit signals and thus they can remain covert, which will reduce the risk of being attacked.
Xiaohua Li, Bo Lu, Wasiq Ali, Jun Su, Haiyan Jin   +4 more
doaj   +1 more source