Results 51 to 60 of about 467,366 (265)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
BuildingsThe free vibration behavior of orthotropic thin plates, which are clamped at three edges and free at one edge, is a matter of great concern in the engineering field.
Zhaoying Wu +4 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Solving the Monge-Amp\`ere Equations for the Inverse Reflector Problem
, 2014 The inverse reflector problem arises in geometrical nonimaging optics: Given a light source and a target, the question is how to design a reflecting free-form surface such that a desired light density distribution is generated on the target, e.g., a ...
Brix, Kolja +2 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Conditional Power and Model Selection Based Sample Size Reestimation with Type I Error Recalibration
Epidemiology, Biostatistics and Public HealthIntroduction The sample size estimation at study design depends on initial assumptions regarding the target power, treatment effect, accrual/follow-up duration and the underlying exponential distribution for time-to-event outcomes.
Michele Pio Di Palma +2 more
doaj +1 more source
, 2010 We use a new configuration-based version of linear response theory to efficiently solve self-consistent mean field equations relating an effective single particle potential to the induced density. The versatility and accuracy of the method is illustrated
John D. Weeks +2 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Pole Allocation Applied to Two Buildings Connected by Joint Damper
Shock and VibrationFor two adjacent buildings connected by a joint damper, an inverse problem is formulated based on the pole allocation method in control theory. The structural system is simplified as a two-degrees-of-freedom (2-DOF) lumped-mass damped shear model.
Yoshiki Ikeda, Yuki Matsumoto
doaj +1 more source