Results 121 to 130 of about 322,032 (291)
Development and Evaluation of the Online Hybrid Model CAMx-LPiG
AtmosphereCAMx-LPiG (Comprehensive Air Quality Model with Extensions—Linear Plume in Grid) is an online hybrid model based on the Chemistry and Transport Model (CTM) CAMx, which includes a sub-grid scale module to simulate the dispersion of linear road traffic ...
Andrea Piccoli +3 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Outer Generalizations of Extending Modules
, 2016 Chapter 5 treats generalized forms of extending modules which are not included in the previous chapter. Specifically, we consider generalized extending forms based on technical machinery conditions like existence of a homomorphism into a direct summand or an equivalence relation on the lattice of submodules etc. (so-called outer generalization).
Tercan, A, Yücel, Canan Celep
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
AlgorithmsThe accurate detection and classification of pavement damage are critical for ensuring timely maintenance and extending the service life of road infrastructure.
Shizheng Zhang +4 more
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
IEEE AccessThis paper proposes a simple, low-cost, and practical hybrid integration design of a 5G FR2 millimeter-wave antenna module based on a thin flexible printed circuit (FPC) and a 5G FR1 microwave antenna based on a metal frame to maximally save precious ...
Huan-Chu Huang, Jie Wu, Shuang Cui
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Jixie chuandong, 2012 A CAD system of CHC type reducer with few teeth difference is developed in Visual Basic 6.0 integrated programming environment.Two modules,calculating for design and parametric drawing are included in the system,which are communicated effectively by ...
陈满意, 黄忠敏, 石永科
doaj